研究成果
研究成果

 

教師姓名
江漢聲
職稱
專任教授
分機
2202
E-mail
053824@mail.fju.edu.tw
學 經 歷
1. 輔仁大學醫務副校長
2. 德國慕尼黑科技大學醫學研究所博士
3. 輔仁大學醫學院院長
4. 台北醫學大學醫學研究所所長
5. 天主教健康照護聯盟理事長
6. 臺灣大學醫學系
專長
1. 泌尿外科
2.男性醫學
3.兩性教育
4.生殖醫學
5.音樂治療
6.醫學教育
7.泌尿道癌症發生學
研究領域
1. 泌尿外科
2. 生殖醫學
3. 兩性醫學
4. 音樂治療
 
 
重要成果詳細內容
Effects of platelet-rich plasma glue placement at the prostatectomy site on erectile function restoration and cavernous nerve preservation in a nerve-sparing prostatectomy rat model

BACKGROUND/PURPOSE: Despite the widespread use of nerve-sparing prostatectomy techniques, the incidence of post-operative erectile dysfunction (ED) remains high. Early intracavernous (IC) injection of platelet-rich plasma (PRP) after nerve crushing improves erectile function (EF) in rats by promoting cavernous nerve (CN) regeneration and preventing structural changes in the corpus cavernosum. However, the neuroprotective effects of the in situ application of PRP glue in rats after CN-sparing prostatectomy (CNSP) remain unclear. AIM: This study aimed to investigate the effects of PRP glue treatment on EF and CN preservation in rats after CNSP. METHODS: After prostatectomy, male Sprague–Dawley rats were treated with PRP glue, IC PRP injection, or their combination. The intracavernous pressure (ICP), mean arterial pressure (MAP), and CN preservation status in the rats were evaluated after 4 weeks. Results were corroborated using histology, immunofluorescence, and transmission electron microscopy. RESULT: The PRP glue-treated rats showed 100% CN preservation and significantly higher ICP responses (the ratio of maximum ICP to MAP (0.79 ± 0.09)) than the CNSP rats (the ratio of maximum ICP to MAP (0.33 ± 0.04)). PRP glue also significantly increased neurofilament-1 expression, indicating its positive effect on the CNs. Furthermore, this treatment significantly increased the expression of α-smooth muscle actin. Electron micrographs revealed that PRP glue preserved the myelinated axons and prevented atrophy of the corporal smooth muscle by maintaining the adherens junctions. CONCLUSIONS: These results indicate that PRP glue is a potential solution for EF preservation by neuroprotection in patients with prostate cancer who are likely to undergo nerve-sparing radical prostatectomy.
 
 
 
 

 


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