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| 學 經 歷 | - 輔仁大學生物醫學暨藥學研究所副教授
澳洲Monash大學訪問學者(2018.06~09)輔仁大學生物醫學暨藥學研究所助理教授成功大學婦產部博士後研究員 成功大學基礎醫學研究所博士
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專 長 | 分子生物學 細胞生物學 生殖生理學 | 研究領域 | 1. 生殖生理
2. 參與造精功能之基因
3. 男性不孕症 |
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| | | | 著作 |  |
| Tsai YL, Lai TH, Liu HC, Wang YY, Lin YH, Ke CC, Chung MT, Chan CC, Lin YH*. Localization Pattes of RAB3C Are Associated with Murine and Human Sperm Formation. Medicina (Kaunas). 2022 Oct 7;58(10):1408. (* corresponding authors) Lin YH, Wang CC, Lin YH, Chen BH. Preparation of Catechin Nanoemulsion from Oolong Tea Leaf Waste and Its Inhibition of Prostate Cancer Cells DU-145 and Tumors in Mice. Molecules. 2021 May 28;26(11):3260. - Lin YH, Huang CY, Ke CC, Wang YY, Lai TH, Liu HC, Ku WC, Chan CC, Lin YH*. ACTN4 Mediates SEPT14 Mutation-Induced Sperm Head Defects. Biomedicines 2020, 8, 518. (* corresponding authors)
- Wang YY, Ke CC, Chen YL, Lin YH, Yu IS, Ku WC, O'Bryan MK, Lin YH*. Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice. PLoS Genet. 2020 25;16(9):e1009020.(* corresponding authors)
Wang YY, Lai TH, Chen MF, Lee HL, Kuo PL, Lin YH*. SEPT14 Mutations and Teratozoospermia: Genetic Effects on Sperm Head Morphology and DNA Integrity. J Clin Med. 2019 Aug 23;8(9). pii: E1297. (* corresponding authors) Wu YN, Chen KC, Wu CC, Lin YH*, Chiang HS*. SLC9A3 Affects Vas Deferens Development and Associates with Taiwanese Congenital Bilateral Absence of the Vas Deferens. Biomed Res Int. 2019 Mar 10;2019: 3562719. (*co-corresponding authors) Yeh CH, Wang YY, Wee SK, Chen MF, Chiang HS, Kuo PL*, Lin YH*. Testis-Specific SEPT12 Expression Affects SUN Protein Localization and is Involved in Mammalian Spermiogenesis. Int J Mol Sci. 2019 Mar 7;20(5). pii: E1163. (*co-corresponding authors) Chiang HS, Wang YY, Lin YH, Wu YN. The role of SLC9A3 in Taiwanese patients with congenital bilateral absence of vas deferens (CBAVD). J Formos Med Assoc. 2019 Feb 20. pii: S0929-6646(18)30529-1. - Ke CC*,Lin YH*, Wang YY, Wu YY, Chen MF, Ku WC, Chiang HS, Lai TH. TBC1D21 Potentially Interacts with and Regulates Rap1 during Murine Spermatogenesis. Int. J. Mol. Sci. 2018, 19(11),3292 (*co-first authors)
Huang CY, Wang YY, Chen YL, Chen MF, Chiang HS, Kuo PL*,Lin YH*.CDC42 Negatively Regulates Testis-Specific SEPT12 Polymerization. Int J Mol Sci. 2018 Sep 5;19(9). pii: E2627. (*co- corresponding authors) Wang YY, Chiang HS, Cheng CY, Wu YN, Lin YC, HC Liu, Tsai WK, Chen YL, Lin YH*. SLC9A3 protein is critical for acrosomal formation in postmeiotic male germ cells. Int J Mol Sci. 2017 Dec 29;19(1). pii: E103 (*corresponding author) - Wang YY*, Lin YH*, Wu YN*, Chen YL, Lin YC, Cheng CY, Chiang HS. Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice. PLoS Genetics. 2017 Apr 6;13(4):e1006715 (*co-first authors)
- Lin YH*, Ke CC*, Wang YY, Chen MF, Chen TM, Ku WC, Chiang HS, Yeh CH. RAB10 Interacts with the Male Germ Cell-Specific GTPase-Activating Protein during Mammalian Spermiogenesis.Int J Mol Sci. 2017 Jan 5;18(1). pii: E97. (*co-first authors)
- Lai TH, Wu YY, Wang YY, Chen MF, Wang P, Chen TM, Wu YN, Chiang HS, Kuo PL, Lin YH*. SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis. Int J Mol Sci. 2016 Nov 16;17(11). pii: E1911.(*corresponding authors)
- Liao CH, Wu YN, Chen BH, Lin YH, Ho HO, Chiang HS. Neuroprotective effect of docosahexaenoic acid nanoemulsion on erectile function in a rat model of bilateral caveous nerve injury. Sci Rep. 2016 Sep 14;6:33040.
- Lin CY, Chen CY, Yu CH, Yu IS, Lin SR, Wu JT, Lin YH, Kuo PL, Wu JC, Lin SW. Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep. 2016 Feb 2;6:20227.
- Liao CH, Chen BH, Chiang HS, Chen CW, Chen MF, Ke CC, Wang YY, Lin WN, Wang CC, Lin YH*. Optimizing a Male Reproductive Aging Mouse Model by D-Galactose Injection. Int J Mol Sci. 2016 Jan 13;17(1). pii: E98. (*corresponding authors)
- Yeh CH, Kuo PL, Wang YY, Wu YY, Chen MF, Lin DY, Lai TH, Chiang HS, Lin YH*. SEPT12/SPAG4/LAMINB1 complexes are required for maintaining the integrity of the nuclear envelope in postmeiotic male germ cells. PLoS One. 2015 Mar 16;10(3):e0120722.(*corresponding authors)
- Kuo YC, Shen YR, Chen HI, Lin YH, Wang YY, Chen YR, Wang CY, Kuo PL. SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins. J Cell Sci. 2015 Mar 1;128(5):923-34.
- Kuo PL, Chiang HS, Wang YY, Kuo YC, Chen MF, Yu IS, Teng YN, Lin SW, Lin YH*. SEPT12-microtubule complexes are required for sperm head and tail formation. Int J Mol Sci. 2013 Nov 7;14(11):22102-16. (*corresponding authors)
- Tasi YC, Chao HC, Chung CL, Liu XY, Lin YM, Liao PC, Pan HA, Chiang HS, KuoPL*, Lin YH*. Characterization of 3-hydroxyisobutyrate dehydrogenase, HIBADH, as a sperm-motility marker. J Assist Reprod Genet. 2013 Apr;30(4):505-12.(*corresponding authors)
- Lin YH*, Wang YY, Chen HI, Kuo YC, Chiou YW, Lin HH, Wu CM, Hsu CC, Chiang HS, Kuo PL. SEPTIN12 genetic variants confer susceptibility to teratozoospermia. PLoS One. 2012;7(3):e34011. (* first author)
- Kuo YC, Lin YH, Chen HI, Wang YY, Chiou YW, Lin HH, Pan HA, Wu CM, Su SM, Hsu CC, Kuo PL. SEPT12 mutations cause male infertility with defective sperm annulus. Hum Mutat. 2012 Apr;33(4):710-9.
- Lin YH*, Lin YM, Kuo YC, Wang YY, Kuo PL. Identification and characterization of a novel Rab GTPase-activating protein in spermatids. Int J Androl. 2011 Oct;34(5 Pt 2):e358-67. (* first author)
- Lin YH*, Kuo YC, Chiang HS, Kuo PL. The role of the septin family in spermiogenesis. Spermatogenesis. 2011 Oct;1(4):298-302. (* first author)
- Lin YH*, Chou CK, Hung YC, Yu IS, Pan HA, Lin SW, Kuo PL. SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos. Fertil Steril. 2011 Jan;95(1):363-5. (* first author)
- Chao HC*, Lin YH*, Kuo YC, Shen CJ, Pan HA, Kuo PL. The expression patte of SEPT7 correlates with sperm morphology. J Assist Reprod Genet. 2010Jun;27(6):299-307. (*co-first authors)
- Lin YH*, Lin YM, Wang YY, Yu IS, Lin YW, Wang YH, Wu CM, Pan HA, Chao SC, Yen PH, Lin SW, Kuo PL. The expression level of septin12 is critical for spermiogenesis. Am J Pathol. 2009 May;174(5):1857-68. (* first author)
- Teng YN, Lin YH, Tsai YC, Hsu CC, Kuo PL, Lin YM. A simplified gene-specific screen for Y chromosome deletions in infertile men. Fertil Steril. 2007 Jun;87(6): 1291-300.
- Lin YH*, Lin YM, Teng YN, Hsieh TY, Lin YS, Kuo PL. Identification of ten novel genes involved in human spermatogenesis by microarray analysis of testicular tissue. Fertil Steril. 2006 Dec;86(6):1650-8. (* first author)
- Cheng YS, Kuo PL, Teng YN, Kuo TY, Chung CL, Lin YH, Liao RW, Lin JS, Lin YM. Association of spermatogenic failure with decreased CDC25A expression in infertile men. Hum Reprod. 2006 Sep;21(9):2346-52.
- Hsu CC, Kuo PL, Chuang L, Lin YH, Teng YN, Lin YM. Uniform deletion junctions of complete azoospermia factor region c deletion in infertile men in Taiwan. Asian J Androl. 2006 Mar;8(2):205-11.
- Lin YM, Teng YN, Chung CL, Tsai WC, Lin YH, Lin JS, Kuo PL. Decreased mRNA transcripts of M-phase promoting factor and its regulators in the testes of infertile men. Hum Reprod. 2006 Jan;21(1):138-44.
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- 2019 獲邀至澳大利亞生殖生物學會會議-口頭報告(澳大利亞,雪梨)
- 2018.06~2018.09 獲科技部補助獲邀至澳大利亞Monash大學訪問 (澳大利亞,墨爾本) (獲科技部107年度補助科學與技術人員國外短期研究補助)
- 2013~2020 獲科技部補助大專校院特殊優秀人才獎勵
- 2016 獲邀至台灣男性學醫學會-口頭報告並獲優秀論文獎
- 2015 獲邀至國際聯合生育學會/日本生殖醫學會聯合會議(IFFS)口頭報告(日本;橫濱),獲優秀論文獎與旅行獎助
- 2015 獲邀至台灣男性學醫學會-口頭報告並獲優秀論文獎
- 2014 獲邀至亞太生殖學會口頭報告 (澳洲布里斯本)
- 2013 獲邀至台灣男性學醫學會-口頭報告
- 2011 獲細生年會優秀壁報論文獎
C. 實驗室成員榮譽 - Wang YY(汪雅雲;博士後). 2021 台灣男性醫學會 江萬煊教授傑出論文獎 , 台灣
- Wang YY(汪雅雲;博班生). 2020 台灣男性醫學會優秀論文獎 , 台灣
- Wang YY(汪雅雲;博班生). 2019 台灣男性醫學會優秀論文獎 , 台灣
- Wang YY(汪雅雲;博班生). 2019 中國生理學會 口頭論文競賽 佳作, 台灣
- Wang YY(汪雅雲;博班生). 2018 中國生理學會 口頭論文競賽 佳作, 台灣
- Liu HC(劉軒哲;碩士生). 2018 劉光義紀念獎 海報論文競賽獲獎, 台灣
- Wang YY(汪雅雲;博班生). 2016 台灣男性醫學會優秀論文獎, 台灣
- Wang YY(汪雅雲;博班生). 2016 生殖與代謝國暨研討會 口頭論文競賽 第二名, 台灣
- Wu YY(吳盈羽,碩班生). 2015 輔仁大學基醫所十周年慶系列活動-壁報論文展覽暨發表會 優等
- Wu YY(吳盈羽,碩班生). 2015 中國生理學會 海報論文競賽 佳作, 台灣
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| | | | 近五年來研究計畫 | |
| Ministry of Science and Technology of Taiwan Grants: Principal Investigator - Identifying the novel disease genes and mutations of teratozoospermia by utilizing whole exome sequencing and mechanistic studies (2022.08- 2025.07; NSTC 111-2320-B-030 -007 -MY3 )
- Revealing the Molecular and Pathological Mechanisms of AGTPBP1 Mutation Caused Teratozoospermia (2021.08-2022.07; MOST 110-2320-B-030-002)
- Through NGS Screening the genetic mutations for teratozoospermia and dissecting the molecular pathological mechanism: a candidate gene AGTPBP1 (2020.08- 2021.07; MOST 109-2320-B-030-002)
- Revealing the Possible Molecular Mechanism of SEPT14 Mutation-Caused Male Infertility (2017.08- 2020.07; MOST 106-2320-B-030-003-MY3)
- Genetic and expression analysis of SEPT12 -interacted partner, SEPTIN14, in the infertile men (1/3)(2/3)(3/3)，(2014.08-2017.07; MOST 103-2314-B-030-002; MOST 104-2314- B-030-001 -; MOST 105-2314-B-030-001 -)
- Using knockout mice to study the roles of testis-specific Rab GTPase-Activing Protein during mammalian spermatogenesis. (2013.08- 2016.07; NSC 102-2320-B-030-006-MY3)
- To study pathological mechanisms of genetic alterations of SEPTIN12 in male infertility and possible therapeutical approaches using transgenic mice (2012.08- 2014.07; NSC 101- 2320 -B- 030-012-MY2)
- Safety studies on nano-cathins and possible therapeutical effects on infertility caused by hyper-oxidation in vivo (2012.08-2013.07; NSC 101 - 2313 - B - 030- 006 -)
Other Grants : Principal Investigator 1. Cathay General Hospital (2013, 2014, 2016, 2017, 2018, 2021) 2. Shin Kong Wu HO-SU Memorial Hospital(2012, 2013, 2014, 2015, 2021) 3. Cardinal Tien Hospital (2013, 2014, 2016, 2017, 2021, 2022) 4. Chi Mei Medical Center (2011, 2016) |
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| | | | 研究室簡介 | |
| 根據統計約有15-20%夫妻有不孕症的困擾，其中30-50%歸類於男性因素。但男性不孕症的病因與治療方式，目前仍有許多尚待突破之瓶頸。我們研究主要在探討男性不孕症中，造成睪丸造精功能不良與先天性雙側輸精管缺損之病因。研究方式是利用分子與細胞生物技術，鑑定參與男性不孕症與先天性輸精管障礙之基因，並設立轉殖小鼠模式，解析其致病機制。進一步，發展可能的檢驗與治療方式，歡迎有興趣參與的暑期生與研究生加入。 |
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