/ / /
最新公告
關於我們
師資陣容
課程資訊
招生資訊
學生專區
儀器資料庫
校友專區
募款專區
師資陣容
師資陣容
教師姓名
林維寧
職 稱
專任教授
分 機
 3398
E-mail
 081551@mail.fju.edu.tw
學 經 歷
  1. 輔仁大學生物醫學暨藥學研究所教授
  2. 輔仁大學生物醫學暨藥學研究所副教授
  3. 輔仁大學生物醫學暨藥學研究所助理教授
  4. 輔仁大學基礎醫學研究所助理教授
  5. 長庚大學博士後研究
專 長
1. 細胞內訊息傳遞
2. 細胞生物學
3. 內分泌學
4. 分子生物學
研究領域

 1. 發炎性疾病訊息傳遞

 2. 肺部發炎的機制探討與中草藥治療開發研究

 3. 發炎性肥胖的機制探討與中草藥介入研究

 
 
 著作
A. 學術期刊論文
 
  1. Fan FY, Vo TTT, Kuo H, Tseng CF, Lin WN, Wu CY, Wu YC, Yang CM, Hsiao LD, Lee IT. Endothelin-1 drives COX-2 and prostaglandin E2 expression in osteoblasts through MAPK/AP-1 signaling during periodontal inflammation. J Dent Sci. 2026 Jul 1;21(3):1411-1424.
  2. Chen YL§, Lin WN§, Pan PY, Ku WC, Wang P, Yip PK, Tsui KC, Wu YN, Lin YH. Generation of a novel Dysferlin microdeletion knock-in mouse model mimicking muscular dystrophy-like pathology. Sci Rep. 2026 Apr 1;16(1):15322. (§Equal contribution)
  3. Chiu SF, Huang CY, Chen CY, Hsu WJ, Yeh YM, Shih YW, Chu LJ, Lin WN, Huang KY. Interactions between bacterial vaginosis-associated microbiota and Trichomonas vaginalis modulate parasite-induced pathogenicity and host immune responses. Parasit Vectors. 2025 Aug 14;18(1):346.
  4. Lai YJ, Chuang YC, Wang YL, Li MT, Lee ES, Lee WJ, Lin WN, Chen YL, Wang CS, Tien Vo TT, Chen YW, Lee IT. Taiwanese green propolis suppresses NLRP3 inflammasome activation and induces Nrf2/HO-1 pathway to reduce periodontal pathogen-induced endothelial inflammation. Arch Oral Biol. 2025 Oct;178:106364.
  5. Huang CY, Chiu SF, Chu LJ, Yeh YM, Huang PJ, Lan KL, Tsai YL, Liu CC, Chen CF, Lin WN, Huang KY. Trichomonas vaginalis extracellular vesicles activate the NLRP3 inflammasome and TLR3-mediated inflammatory cascades in host cells. PLoS Pathog. 2025 Jun 2;21(6):e1013216.
  6. Liu CC, Chu LJ, Yeh YM, Lin HC, Chen LC, Huang CY, Chiu SF, Cheng FW, Lin WN, Huang KY. Immunomodulatory roles of autophagic flux and IFIT in human ectocervical cells upon Trichomonas vaginalis infection. Int Immunopharmacol. 2025 May 16;155:114643.
  7. Lee IT, Yang CC, Lin YJ, Wu WB, Lin WN, Lee CW, Tseng HC, Tsai FJ, Hsiao LD, Yang CM. Mevastatin-Induced HO-1 Expression in Cardiac Fibroblasts: A Strategy to Combat Cardiovascular Inflammation and Fibrosis. Environ Toxicol. Environ Toxicol. 2025 Feb;40(2):264-280.
  8. Yeh CH, Lin CH, Ma TL, Peng TY, Vo TTT, Lin WN, Chen YH, Lee IT. Comparison Between Powered and Manual Toothbrushes Effectiveness for Maintaining an Optimal Oral Health Status. Clin Cosmet Investig Dent. 2024 Oct 2;16:381-396.
  9. Chang CC, Sia KC, Lin CM, Wang PC, Lin WN. Lipopolysaccharide modified brown adipose tissue lipolysis and mitogenesis via up-regulation of cPLA2 and COX-2 expression. Fu-Jen Joual of Medicine. 2024 Sep; 9:p.01-13. (Corresponding author)
  10. Wang PC, Lin WN. Prior Bariatric Surgery Predicts Lower Life-Threatening Morbidity in Patients Admitted for Acute Allergic Reaction and Anaphylaxis: a Propensity Score-Matched Analysis of the U.S. Nationwide Inpatient Sample, 2005-2018. Obes Surg. 2024 Sep;34(9):3258-3265. (Corresponding author)
  11. Chang CC, Liu TC, Lu CJ, Chiu HC, Lin WN. Explainable machine leaing model for identifying key gut microbes and metabolites biomarkers associated with myasthenia gravis. Comput Struct Biotechnol J. 2024 Apr 10;23:1572-1583. (Corresponding author)
  12. Chen YL, Wu WB, Wang P, Yip PK, Wu YN§, Lin YH§, Lin WN§. Novel five nucleotide deletion in dysferlin leads to autosomal recessive limb-girdle muscular dystrophy. Physiol Rep. 2023 Dec;11(24):e15887. (Co-Corresponding author)
  13. Chang CC, Liu TC, Lu CJ, Chiu HC, Lin WN. Machine leaing strategy for identifying altered gut microbiomes for diagnostic screening in myasthenia gravis. Front Microbiol. 2023 Sep 27;14:1227300. (Corresponding author)(§Equal contribution)
  14. Huang LS, Yeh YM, Chiu SF, Huang PJ, Chu LJ, Huang CY, Cheng FW, Chen LC, Lin HC, Shih YW, Lin WN, Huang KY. Intestinal microbiota analysis of different Blastocystis subtypes and Blastocystis-negative individuals in Taiwan. Biomed J. 2023 Sep 27:100661.
  15. Wang PC, Ho KC, Ko WC, Lin WN. Impact of prior bariatric surgery on outcomes of hospitalized patients with systemic lupus erythematosus: a propensity score-matched analysis of the U.S. nationwide inpatient sample. Surg Obes Relat Dis. 2023 Dec;19(12):1382-1390. (Corresponding author)
  16. Vo TTT, Huynh TD, Wang CS, Lai KH, Lin ZC, Lin WN, Chen YL, Peng TY, Wu HC, Lee IT. The Potential Implications of Hydrogen Sulfide in Aging and Age-Related Diseases through the Lens of Mitohormesis. Antioxidants (Basel). 2022 Aug 20;11(8):1619.
  17. Chang CC, Sia KC, Chang JF, Lin CM, Yang CM, Lee IT, Vo TTT, Huang KY, Lin WN. Participation of lipopolysaccharide in hyperplasic adipose expansion: Involvement of NADPH oxidase/ROS/p42/p44 MAPK-dependent Cyclooxygenase-2. J Cell Mol Med. 2022 Jul;26(14):3850-3861. (Corresponding author)
  18. Chang JF, Kuo HL, Liu SH, Hsieh CY, Hsu CP, Hung KC, Wang TM, Wu CC, Lu KC, Lin WN, Hung CF, Ko WC. Translational Medicine in Uremic Vascular Calcification: Scavenging ROS Attenuates p-Cresyl Sulfate-Activated Caspase-1, NLRP3 Inflammasome and Eicosanoid Inflammation in Human Arterial Smooth Muscle Cells. Life (Basel). 2022 May 23;12(5):769.
  19. Yang CC, Hsiao LD, Wang CY, Lin WN, Shih YF, Chen YW, Cho RL, Tseng HC, Yang CM. HO-1 Upregulation by Kaempferol via ROS-Dependent Nrf2-ARE Cascade Attenuates Lipopolysaccharide-Mediated Intercellular Cell Adhesion Molecule-1 Expression in Human Pulmonary Alveolar Epithelial Cells. Antioxidants (Basel). 2022 Apr 14;11(4):782.
  20. Hsu CY, Vo TTT, Lee CW, Chen YL, Lin WN, Cheng HC, Vo QC, Lee IT. Carbon monoxide releasing molecule-2 attenuates angiotensin II-induced IL-6/Jak2/Stat3-associated inflammation by inhibiting NADPH oxidase- and mitochondria-derived ROS in human aortic smooth muscle cells. Biochem Pharmacol. 2022 Apr;198:114978.
  21. Huang PJ, Huang CY, Li YX, Liu YC, Chu LJ, Yeh YM, Cheng WH, Chen RM, Lee CC, Chen LC, Lin HC, Chiu SF, Lin WN, Lyu PC, Tang P, Huang KY. Dissecting the Transcriptomes of Multiple Metronidazole-Resistant and Sensitive Trichomonas vaginalis Strains Identified Distinct Genes and Pathways Associated with Drug Resistance and Cell Death. Biomedicines. 2021 Dec 2;9(12):1817.
  22. Chiu SF, Huang PJ, Cheng WH, Huang CY, Chu LJ, Lee CC, Lin HC, Chen LC, Lin WN, Tsao CH, Tang P, Yeh YM, Huang KY. Vaginal Microbiota of the Sexually Transmitted Infections Caused by Chlamydia trachomatis and Trichomonas vaginalis in Women with Vaginitis in Taiwan. Microorganisms. 2021 Sep 2;9(9):1864.
  23. Vo TTT, Hsu CY, Wee Y, Chen YL, Cheng HC, Wu CZ, Lin WN, Lee IT. Carbon Monoxide-Releasing Molecule-2 Ameliorates Particulate Matter-Induced Aorta Inflammation via Toll-Like Receptor/NADPH Oxidase/ROS/NF-κB/IL-6 Inhibition. Oxid Med Cell Longev. 2021 Jul 13;2021:2855042.
  24. Vo TTT, Liu JF, Wu CZ, Lin WN, Chen YL, Lee IT. Surfactin from Bacillus subtilis induces apoptosis in human oral squamous cell carcinoma through ROS-regulated mitochondrial pathway. J Cancer. 2020 Oct 21;11(24):7253-7263.
  25. Vo TTT, Lee CW, Wu CZ, Liu JF, Lin WN, Chen YL, Hsu LF, Tsai MH, Lee IT. Surfactin from Bacillus subtilis attenuates ambient air particulate matter-promoted human oral cancer cells metastatic potential. J Cancer. 2020 Aug 18;11(20):6038-6049.
  26. Cheng CY, Vo TTT, Lin WN, Huang HW, Chuang CC, Chu PM, Lee IT. Nrf2/HO-1 Partially Regulates Cytoprotective Effects of Carbon Monoxide Against Urban Particulate Matter-Induced Inflammatory Responses in Oral Keratinocytes. Cytokine. 2020 Jun 29;133:155185.
  27. Lin HC, Chu LJ, Huang PJ, Cheng WH, Zheng YH, Huang CY, Hong SW, Chen LC, Lin HA, Wang JY, Chen RM, Lin WN, Tang P, Huang KY. Proteomic signatures of metronidazole-resistant Trichomonas vaginalis reveal novel proteins associated with drug resistance. Parasit Vectors. 2020 Jun 1;13(1):274.
  28. Chang JF, Chou YS, Wu CC, Chen PC, Ko WC, Liou JC, Hsieh CY, Lin WN, Wen LL, Chang SW, Tung TH, Wang TM. A Joint Evaluation of Neurohormone Vasopressin-Neurophysin II-Copeptin and Aortic Arch Calcification on Mortality Risks in Hemodialysis Patients. Front Med (Lausanne). 2020 Mar 31;7:102.
  29. Chang JF, Liu SH, Lu KC, Ka SM, Hsieh CY, Ho CT, Lin WN, Wen LL, Liou JC, Chang SW, Wu CC, Wang TM, Li YY. Uremic Vascular Calcification Is Correlated With Oxidative Elastic Lamina Injury, Contractile Smooth Muscle Cell Loss, Osteogenesis, and Apoptosis: The Human Pathobiological Evidence. Front Med (Lausanne). 2020 Mar 24;7:78.
  30. Chung IC, Yuan SN, OuYang CN, Hu SI, Lin HC, Huang KY, Lin WN, Chuang YT, Chen YJ, Ojcius DM, Chang YS, Chen LC. EFLA 945 restricts AIM2 inflammasome activation by preventing DNA entry for psoriasis treatment. Cytokine. 2020 Mar;127:154951.
  31. Lin CC, Lin WN, Cho RL, Yang CC, Yeh YC, Hsiao LD, Tseng HC, Yang CM. Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation. J Clin Med. 2020 Jan 15;9(1). pii: E226.
  32. Chang JF, Yeh JC, Ho CT, Liu SH, Hsieh CY, Wang TM, Chang SW, Lee IT, Huang KY, Wang JY, Lin WN. Targeting ROS and cPLA2/COX2 Expressions Ameliorated Renal Damage in Obese Mice with Endotoxemia. Int J Mol Sci. 2019 Sep 6;20(18). pii: E4393. (Corresponding author)
  33. Lee CW, Chi MC, Hsu LF, Yang CM, Hsu TH, Chuang CC, Lin WN, Chu PM, Lee IT. Carbon monoxide releasing molecule-2 protects against particulate matter-induced lung inflammation by inhibiting TLR2 and 4/ROS/NLRP3 inflammasome activation. Mol Immunol. 2019 Aug;112:163-174.
  34. Hsu PS, Lin CM, Chang JF, Wu CS, Sia KC, Lee IT, Huang KY, Lin WN. Participation of NADPH Oxidase-Related Reactive Oxygen Species in Leptin-Promoted Pulmonary Inflammation: Regulation of cPLA2α and COX-2 Expression. Int J Mol Sci. 2019 Mar 2;20(5). pii: E1078. (Corresponding author)
  35. Chang CC, Sia KC, Chang JF, Lin CM, Yang CM, Huang KY, Lin WN. Lipopolysaccharide promoted proliferation and adipogenesis of preadipocytes through JAK/STAT and AMPK-regulated cPLA2 expression. Int J Med Sci. 2019 Jan 1;16(1):167-179. (Corresponding author)
  36. Huang KY, Chen RM, Lin HC, Cheng WH, Lin HA, Lin WN, Huang PJ, Chiu CH, Tang P. Potential role of autophagy in proteolysis in Trichomonas vaginalis. J Microbiol Immunol Infect. 2019 Apr;52(2):336-344.
  37. Yeh JC, Wu CC, Choy CS, Chang SW, Liou JC, Chen KS, Tung TH, Lin WN, Hsieh CY, Ho CT, Wang TM, Chang JF. Non-Hepatic Alkaline Phosphatase, hs-CRP and Progression of Vertebral Fracture in Patients with Rheumatoid Arthritis: A Population-Based Longitudinal Study. J Clin Med. 2018 Nov 13;7(11). pii: E439.
  38. Tsai MH, Wu CH, Lin WN, Cheng CY, Chuang CC, Chang KT, Jiang RS, Hsu JF, Lee IT. Infection with Staphylococcus aureus elicits COX-2/PGE2/IL-6/MMP-9-dependent aorta inflammation via the inhibition of intracellular ROS production.  Biomed Pharmacother. 2018 Nov;107:889-900.
  39. Ko WC, Choy CS, Lin WN, Chang SW, Liou JC, Tung TH, Hsieh CY, Chang JF. Galectin-3 Interacts with Vascular Cell Adhesion Molecule-1 to Increase Cardiovascular Mortality in Hemodialysis Patients. J Clin Med. 2018 Sep 24;7(10). pii: E300.
  40. Tsai MH, Yang CM, Chang KT, Chuang CC, Lin WN, Jiang RS, Wu CH, Lee IT. Carbon monoxide ameliorates Staphylococcus aureus-elicited COX-2/IL-6/MMP-9-dependent human aortic endothelial cell migration and inflammatory responses. Immunol Lett. 2018 Nov;203:40-49.
  41. Chang JF, Liang SS, Thanasekaran P, Chang HW, Wen LL, Chen CH, Liou JC, Yeh JC, Liu SH, Dai HM, Lin WN. Translational Medicine in Pulmonary-Renal Crosstalk: Therapeutic Targeting of p-Cresyl Sulfate Triggered Nonspecific ROS and Chemoattractants in Dyspneic Patients with Uremic Lung Injury. J Clin Med. 2018 Sep 9;7(9). pii: E266. (Corresponding author)
  42. Cho RL, Lin WN, Wang CY, Yang CC, Hsiao LD, Lin CC, Yang CM. Heme oxygenase-1 induction by rosiglitazone via PKCα/AMPKα/p38 MAPKα/SIRT1/PPARγ pathway suppresses lipopolysaccharide-mediated pulmonary inflammation. Biochem Pharmacol. 2018 Feb;148:222-237.
  43. Lin CC, Chiang YC, Cho RL, Lin WN, Yang CC, Hsiao LD, Yang CM. Up-regulation of PYK2/PKCα-dependent haem oxygenase-1 by CO-releasing molecule-2 attenuates TNF-α-induced lung inflammation. Br J Pharmacol. 2018 Feb;175(3):456-468.
  44. Lin CC§, Lin WN§, Cho RL, Wang CY, Hsiao LD, Yang CM. TNF-alpha-induced cPLA2 expression via NADPH oxidase/reactive oxygen species-dependent NF-kappaB cascade on human pulmonary alveolar epithelial cells. Front Pharmacol. 2016 Nov 25;7:447. eCollection 2016. (§Equal contribution)
  45. Chen HM, Yang CM, Chang JF, Wu CS, Sia KC, Lin WN. AdipoR-increased intracellular ROS promotes cPLA2 and COX-2 expressions via activation of PKC and p300 in adiponectin-stimulated human alveolar type II cells. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L255-69. (Corresponding author)
  46. Liao CH, Chen BH, Chiang HS, Chen CW, Chen MF, Ke CC, Wang YY, Lin WN, Wang CC, Lin YH. Optimizing a Male Reproductive Aging Mouse Model by d-Galactose Injection. Int J Mol Sci. 2016 Jan 13;17(1). pii: E98.
  47. Hsu PS, Wu CS, Chang JF, Lin WN. Leptin Promotes cPLA₂ Gene Expression through Activation of the MAPK/NF-κB/p300 Cascade. Int J Mol Sci. 2015 Nov 18;16(11):27640-58. (Corresponding author)
  48. Lin CC§, Lin WN§, Hou WC, Hsiao L, Yang CM. Endothelin-1 Induces VCAM-1 Expression-Mediated Inflammation via Receptor Tyrosine Kinases and Elk/p300 in Human Tracheal Smooth Muscle Cells. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 1;309(3):L211-25. (§Equal contribution)
  49. Lee IT, Lin CC, Lin WN, Wu WL, Hsiao LD, Yang CM. Lung inflammation caused by adenosine-5'-triphosphate is mediated via Ca(2+)/PKCs-dependent COX-2/PGE2 induction. Int J Biochem Cell Biol. 8:1657-68, 2013.
  50. Lin CC, Lee IT, Wu WL, Lin WN, Yang CM. Adenosine triphosphate regulates NADPH oxidase activity leading to hydrogen peroxide production and COX-2/PGE2 expression in A549 cells. Am J Physiol Lung Cell Mol Physiol. 303:L401-L412, 2012.
  51. Lin CC§, Lin WN§, Cheng SE, Tung WH, Wang HH, Yang CM. Transactivation of EGFR/PI3K/Akt involved in ATP-induced inflammatory protein expression and cell motility. J Cell Physiol. 227:1628-1638, 2012. (§Equal contribution)
  52. Lin WN§, Lin CC§, Cheng HY, Yang CM. Regulation of cyclooxygenase-2 and cytosolic phospholipase A2 gene expression by lipopolysaccharide through the RNA-binding protein HuR: involvement of NADPH oxidase, reactive oxygen species and mitogen-activated protein kinases. Br J Pharmacol. 163:1691-1706, 2011. (§Equal contribution)
  53. Lee CW, Lee IT, Lin CC, Lee HC, Lin WN, Yang CM. Activation and induction of cytosolic phospholipase A2 by IL-1beta in human tracheal smooth muscle cells: role of MAPKs/p300 and NF-kB. J Cell Biochem. 109:1045-1056, 2010.
  54. Lin WN, Luo SF, Lin CC, Hsiao LD, Yang CM. Differential involvement of PKC-dependent MAPKs activation in lipopolysaccharide-induced AP-1 expression in human tracheal smooth muscle cells. Cell Signal. 21:1385-1395, 2009.
  55. Luo SF, Chang CC, Lee IT, Lee CW, Lin WN, Lin CC, Yang CM. Activation of ROS/NF-kB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1b-treated human tracheal smooth muscle cells. Toxicol Appl Pharmacol. 237:8-21, 2009.
  56. Lin CC§, Lin WN§, Wang WJ, Sun CC, Tung WH, Wang HH, Yang CM. Functional coupling expression of COX-2 and cPLA2 induced by ATP in rat vascular smooth muscle cells: role of ERK1/2, p38 MAPK, and NF-kB. Cardiovasc Res. 82:522-531, 2009. (§Equal contribution)
  57. Luo SF, Lin CC, Chen HC, Lin WN, Lee IT, Lee CW, Hsiao LD, Yang CM. Involvement of MAPKs, NF-kB and p300 co-activator in IL-1b-induced cytosolic phospholipase A2 expression in canine tracheal smooth muscle cells. Toxicol Appl Pharmacol. 232:396-407, 2008.
  58. Lin WN, Luo SF, Wu CB, Lin CC, Yang CM. Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: Involvement of Src/EGFR/PI3-K/Akt pathway. Toxicol Appl Pharmacol. 228:256-268, 2008.
  59. Lin WN, Luo SF, Lee CW, Wang CC, Wang JS, Yang CM. Involvement of p42/p44 MAPK, p38 MAPK, JNK and NF-kB in LPS-induced VCAM-1 expression in human tracheal smooth muscle cells. Cell Signal. 19:1258-1267, 2007.
  60. Lee CW, Lin CC, Lin WN, Liang KC, Luo SF, Wu CB, Wang SW, Yang CM. TNF-a induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-kB/p300 binding in human tracheal smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 292: L799-L812, 2007.
  61. Liang KC, Lee CW, Lin WN, Lin CC, Wu CB, Luo SF, Yang CM. Interleukin-1β induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK and nuclear factor-kB signaling pathways in human tracheal smooth muscle cells. J Cell Physiol. 211:759-770, 2007.
  62. Lee CW, Lin WN, Lin CC, Luo SF, Wang JS, Pouyssegur J, Yang CM. Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-a in human tracheal smooth muscle cells: Involvement of MAPKs, NF-kB, p300, and histone acetylation. J Cell Physiol. 207: 174-186, 2006.
  63. Luo SF, Lin WN, Yang CM, Lee CW, Liao CH, Leu YL, Hsiao LD. Induction of cytosolic phospholipase A2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of MAPKs and NF-kB pathways. Cell Signal. 18: 1201-1211, 2006.
  64. Wang CC, Lin WN, Lee CW, Lin CC, Luo SF, Wang JS, Yang CM. Involvement of p42/p44 MAPK, p38 MAPK, JNK and NF-kB in interleukin-1b-induced VCAM-1 expression in human tracheal smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 288: L227-L237, 2005.
    B. 學術會議論文
    1. 沈怡廷, 林維寧. Melatonin changed inflammation-mediated adiposity. The 32th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2017. Poster.
     
    2. Sia KC, Lin WN. Lipopolysaccharide modulated adiposity through JAK/ROS-related inflammation. The 32th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2017. Poster.
     
    3. Jiao DH, Lin WN. Melatonin Abolished LPS and TNF-a-mediated Pulmonary Inflammation via Decreasing Intracellular Reactive Oxygen Species.  The 31th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2016. Poster.
     
    4. Chang JF, Dai HN, Lin WN. Participation of Reactive Oxygen Species on p-Cresyl Sulfate Reduced Juman Type II Epithelial Cells Viability.  The 31th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2016. Poster.
     
    5. Sia KC, Lin WN. LPS facilitated obesity through evaluated cPLA2 expression via JAK-STAT and AMPK pathway. The 31th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2016. Poster. (中國生理學會105年度海報論文競賽第三名)
     
    6. Sia KC, Wu CS, Lin WN. LPS facilitated preadipocytes proliferation via NADPH oxidase/ROS-dependent expression of cyclooxygenase-2. The 30th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2015. Poster.
     
    7. Wu CS, Hsu PS, Lin WN. Leptin modulated the occurrence of lung inflammation by increased expression of cPLA2 and COX‐2 via NADPH oxidase/ROS‐dependent activation of AP‐1. The 30th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2015. Poster. (中國生理學會104年度優秀論文獎第二名).
     
    8. Hsu PS, Wu CS, Lin WN. Enhancement of lung inflammatory protein expression by leptin via MAPK, NF-kappaB and p300. 102年度形態及生理醫學學門新知暨學術交流研討會. Poster.
     
    9. Chen HM, Lin WN. Adiponectin Modulated Expression of Cytosolic Phospholipase A2 and Cyclooxygenase-2 via Accumulation of ROS and Activation of PKC/p300 in the Pulmonary Alveolar Type II Cells. The 29th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2015. Poster.
     
    10. Lin WN, Tung WH, Wang HH, Yang CM. Functional Coupling Expression of COX-2 and cPLA2 Induced by ATP in Rat Vascular Smooth Muscle Cells. The 9th World Congress on Inflammation, Tokyo, Japan. July6-10, 2009. Poster.
     
    11. Lin WN, Yang CM. Up-regulation of VCAM-1 Ehanced Leukocytes Recruitment to the Lung in LPS-induced Airway Diseases. The 24th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2009. Poster..
     
    12. Lin WN, Yang CM. LPS Induces VCAM-1 Expression via Src/EGFR/PI3-K/Akt Pathway in Human Tracheal Smooth Muscle Cells. 32nd FEBS Congress on Molecular Machines, Vienna, Austria. July 7-12, 2007. Poster.
     
    13. Lin WN, Yang CM. LPS Induces VCAM-1 Expression via Src/EGFR/PI3-K/Akt Pathway in Human Tracheal Smooth Muscle Cells. 32nd FEBS Congress on Molecular Machines, Vienna, Austria. July 7-12, 2007. Poster.
 
近五年來研究計劃
1. 細菌內毒素對於細胞肥大型肥胖的影響(2015/08-2016/07)

2.褪黑激素藉由調控細胞內氧化壓力平衡減緩肺部發炎的作用(2015/01-2015/12)

3.內毒素藉由環氧化酶2調控前脂肪細胞的生長(2014/08-2015/07)

4.細胞磷脂酶A2在內毒素調控前脂肪細胞增生中的角色(2013/08-2014/07)

5. 瘦素調控小鼠急性與慢性發炎的作用(2014/01-2014/12)

6.細菌感染對於脂肪生成的影響: 與脂肪增生和肥大的相關性 (國科會NSC-102-2320-B-030-001-, 2013/08 至 2014/07)

7. 探討瘦素調控肺泡第二型細胞表現環氧化酶-2的機轉 (2013/01 至 2013/12)

8. NADPH oxidase/ROS/CREB路徑參與在瘦素刺激人類肺泡第II型表皮細胞誘發細胞溶質磷脂酶表現 (2013/01/01 至 2013/12/31) 

9. 由綠茶茶葉渣製備兒茶素奈米微乳化液及其對生物活性的影響─奈米化兒茶素對於脂肪代謝的機轉探討：對水通道蛋白3、7、9的調控作用 (國科會NSC 101-2313-B-030-007, 2012/08 至 2013/07)

10. 內毒素調控前脂肪細胞增生的機轉 (2012/08/ 至 2013/07)

11. 瘦素刺激人類肺泡第II型表皮細胞誘發細胞溶質磷脂酶表現: MAPK、AMPK和p300的參與 (2012/01 至 2012/12)

12. 探討瘦素調控肺部細胞表現細胞內黏附分子的機轉（亞東醫院, 2011/08 至 2012/07）

13.  探討adipokine 調控肺部發炎相關機制（新光醫院, 2011/01至 2011/12）
 
 研究室簡介
肥胖是一種慢性疾病，除了會衍生多種威脅生命如胰島素阻抗症候群和心血管疾病的發生外，根據研究指出，肥胖也與阻塞型睡眠呼吸中止症候群、慢性阻塞性肺病以及氣喘有關，但是相關調控機制還未被了解。另一方面，研究也發現發炎反應會伴隨包括氣喘和阻塞型睡眠呼吸中止症候群等多種急慢性肺部疾病的產生，此時發炎性基因如黏著分子會啟動表現，進而調控放大發炎反應的發生。本實驗室以脂肪細胞合成釋放的瘦素(leptin)與脂聯素(adiponectin)作用於肺部細胞，探討瘦素和脂聯素刺激細胞後所引發的發炎基因表現以及其相關的分子機轉。另一方面，我們也利用肺部細胞所釋放的發炎介質作用於脂肪組織，以期了解肺部系統與脂肪組織之間的相互影響作用。
 

Copyright c2009 Graduate Institute of Biomedical and Pharmaceutical Science 輔仁大學生物醫學暨藥學研究所
所辦電話：02-29053426所長電話：02-29053412Email：GIBPS@mail.fju.edu.tw