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Current
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Specialty
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- Cancer Biology
- Molecular Biology
- Tumor Biology
- Cell Biology Biotechnology (Gene Regulation)
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Research / Course
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1. Metastasis-related gene functional and transcriptional regulation study
2. Effects of chinese herb extracts on cancer cell activities |
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1. Yi-Hsin Tseng, Wen-Ru Chou, Wei-Lun Liu, Zhong-Xuan Dung, Ching-Hao Lin, Chia-Hung Hsieh, Chi-Chung Wang*. (2024) Effects of methylation and transcription factor YY1 on ID2 expression in non–small cell lung carcinoma cells. Am. J. Cancer Res. 14(5): 2424-2438. (SCI)
2. Jung-Ying Chiang, Sung-Tai Wei, Huan-Jui Chang, Der-Cheg Chen, Hwai-Lee Wang, Fu-Ju Lei, Kai-Yu Wei, Yen‐Chih Huang, Chi-Chung Wang, Chia-Hung Hsieh*. (2024) ABCC4 suppresses glioblastoma progression and recurrence by restraining cGMP-PKG signalling. Br. J. Cancer 130:1324–1336. (SCI)
3. Fu-Ju Lei, Jung-Ying Chiang, Huan-Jui Chang, Der-Cheg Chen, Hwai-Lee Wang, Hsi-An Yang, Kai-Yu Wei, Yen‐Chih Huang, Chi-Chung Wang, Sung-Tai Wei, Chia-Hung Hsieh*. (2023) Cellular and exosomal GPx1 are essential for controlling hydrogen peroxide balance and alleviating oxidative stress in hypoxic glioblastoma. Redox Biol. 65:102831. (SCI)
4. Liang-Kun Chen, Ching-Chi Hsieh, Yi-Chao Huang, Yuan-Jung Huang, Chun-Fan Lung, Wei-En Hsu, Chao-Ling Yao, Tsung-Yu Tseng, Chi-Chung Wang, Yi-Chiung Hsu*. (2023) Mechanical Stretch Promotes Invasion of Lung Cancer Cells via Activation of Tumor Necrosis Factor-alpha. Biotechnology and Bioprocess Engineering 28:1-6.
5. Sung-Tai Wei, Jung-Ying Chiang, Hwai-Lee Wang, Fu-Ju Lei, Yen‐Chih Huang, Chi-Chung Wang, Der-Yang Cho, Chia-Hung Hsieh*. (2023) Hypoxia-induced CXCL14 expression drives protumorigenic effects via activation of IGF-1R signaling in glioblastoma. Cancer Sci. 114:174-186. (SCI)
6. Jian-Ting Chen, Yuan-Ling Hsu, Yi-Chiung Hsu, Yi-Hsin Tseng, Ming-Han Liu, Chia-Wei Weng, Ching-Hao Lin, Szu-Hua Pan, Jeremy JW Chen, Chi-Chung Wang*. (2022) Id2 exerts tumor suppressor properties in lung cancer through its effects on cancer cell invasion and migration. Front. Oncol. 12: 801300. (SCI)
7. Jung-Ying Chiang, Fu-Ju Lei, Huan-Jui Chang, Sung-Tai Wei, Chi-Chung Wang, Yen‐Chih Huang, Hwai-Lee Wang, Shu-Yu Hu, Chi-Fen Chuang, Chia-Hung Hsieh*. (2022) Haloperidol instigates endometrial carcinogenesis and cancer progression by the NF-κB/CSF-1 signaling cascade. Cancers 14 (13): 3089. (SCI)
8. Yu-Hsuan Kuo, Yi-Xuan Wang, Wan-Hua Peng, Nian-Yu Chi, Tzong-Huei Lee, Chi-Chung Wang*. (2022) Coriloxin exerts antitumor effects in human lung adenocarcinoma cells. Int. J. Mol. Sci. 23 (7): 3991. (SCI)
9. Chi-Chung Wang#, Sheng-Yi Lin#, Yu-Han Huang, Chia-Hung Hsieh, Hsiu-Hui Chang, Hsuan-Yu Chen, Chia-Wei Weng, Gee-Chen Chang, Sung-Liang Yu, Jeremy J.W. Chen. (2021) Paired-like homeodomain 2B contributes to tumour progression and anti-autophagy in human lung cancer. Am. J. Cancer Res. 11(10): 4900-4918. (# Equal contributors) (SCI)
10. Yu-Hsiang Lin, Chi-Chung Wang, Ying-Hung Lin, Bing-Huei Chen*. (2021) Preparation of catechin nanoemulsion from oolong tea leaf waste and its inhibition on prostate cancer cells DU-145 and tumors in mice. Molecules 26(11): 3260. (SCI)
11. Shih-Sen Lin, Chia-Mo Lin, Yi-Chiung Hsu, Chi-Chung Wang*. (2021) Comorbidities in lung cancer: A nationwide population-based study in Taiwan. Fu-Jen J. Med. 19(1): 1-11.
12. Bing-Huei Chen, Chia-Hung Hsieh, Su-Yun Tsai, Chian-Yu Wang, Chi-Chung Wang*. (2020) Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway. Sci. Rep. 10: 5163. (SCI)
13. Chi-Chung Wang, Yuan-Ling Hsu, Chi-Jen Chang, Chia-Jen Wang, Tzu-Hung Hsiao, Szu-Hua Pan*. (2019) Inhibitor of DNA-binding protein 4 inhibits cancer metastasis through regulation of epithelial mesenchymal transition in non-small cell lung cancer. Cancers 11(12): 2021. (SCI)
14. John Tung Chien, Ru-Hui Chang, Chia-Hung Hsieh, Chih-Yu Hsu, Chi-Chung Wang*. (2018) Antioxidant property of Taraxacum formosanum Kitam and its antitumor activity in non-small-cell lung cancer cells. Phytomedicine 49(2018): 1-10. (SCI)
15. Chi-Jen Chang, Yen-Lin Chen, Chia-Hung Hsieh, Ya-Jung Liu, Sung-Liang Yu, Jeremy J.W. Chen, Chi-Chung Wang*. (2017) HOXA5 and p53 cooperate to suppress lung cancer cell invasion and serve as good prognostic factors in non-small cell lung cancer. J. Cancer 8(6): 1071-1081. (SCI)
16. Yu-Jung Lin, Woei-Cheg Shyu, Chi-Wei Chang, Chi-Chung Wang, Chung-Pu Wu, Hsu-Tung Lee, Liang-Jwu Chen, Chia-Hung Hsieh*. (2017) Tumor Hypoxia Regulates Forkhead Box C1 to Promote Lung Cancer Progression. Theranostics 7(5): 1177-91. (SCI)<
17. Chun-Hou Liao, Bin-Huei Chen, Han-Sun Chiang, Chiu-Wei Chen, Mei-Feng Chen, Chih-Chun Ke, Wei-Ning Lin, Chi-Chung Wang, Ying-Hung Lin*. (2016) Optimizing a male reproductive aging mouse model by D-Galactose injection. Int. J. Mol. Sci. 17: 98. (SCI)
18. Wei-Ling Chen, Chi-Chung Wang, Yu-Jung Lin, Chung-Pu Wu and Chia-Hung Hsieh*. (2015) Cycling hypoxia induces chemoresistance through the activation of reactive oxygen species-mediated B-cell lymphoma extra-long pathway in glioblastoma multiforme. J. Transl. Med. 13: 389. (SCI)
19. Chi-Chung Wang, Wei-Chih Chen, Chi-Feng Hung and Vinchi Wang*. (2015) Cellular Responses by Low-power He-Ne laser Irradiation on Human Lung Cancer Cells. J Nucl Med Radiat Ther 6: 234.
20. Chi-Chung Wang, Kang-Yi Su, Hsuan-Yu Chen, So-Yi Chang, Chi-Fan Shen, Chia-Hung Hsieh, Qi-Sheng Hong, Ching-Cheng Chiang, Gee-Chen Chang, Sung-Liang Yu* and Jeremy J.W. Chen*. (2015) HOXA5 inhibits metastasis via regulating cytoskeletal remodelling and associates with prolonged survival in non-small-cell lung carcinoma. PLoS ONE 10(4):e0124191. (SCI)
21. Chia-Hung Hsieh*, Yu-Jung Lin, Chung-Pu Wu, Hsu-Tung Lee, Woei-Cheg Shyu*, Chi-Chung Wang*. (2015) Livin contributes to tumor hypoxia-induced resistance to cytotoxic therapies in glioblastoma multiforme. Clin. Cancer Res. 2015, 21: 460-70. (SCI)
22. Meng-Feng Tsai, Chi-Chung Wang, Jeremy J.W. Chen*. (2014) Tumour suppressor HLJ1: a potential diagnostic, preventive and therapeutic target in non-small cell lung cancer. World J. Clin. Oncol. 5: 865-73.
23. Yi-Hua Lai, Sung-Liang Yu, Hsuan-Yu Chen, Chi-Chung Wang, Huei-Wen Chen, Jeremy J.W. Chen* .(2013) The HLJ1-targeting drug-screening identified Chinese herb andrographolide that can suppress tumour growth and invasion in non-small-cell lung cancer. Carcinogenesis 34: 1069-80. (SCI)
24. Chii-Wen Chou, Chi-Chung Wang, Chung-Pu Wu, Yu-Jung Lin, Yu-Chun Lee, Ya-Wen Cheng, Chia-Hung Hsieh*. (2012) Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1. Neuro Oncol. 14:1227-38. (SCI)
25. Chi-Chung Wang, Sheng-Yi Lin, Yi-Hua Lai, Ya-Jung Liu, Yuan-Lin Hsu, Jeremy J. W. Chen*. (2012) Dimethyl sulfoxide promotes the multiple functions of the tumor suppressor HLJ1 through Activator Protein-1 activation in NSCLC cells. PLoS ONE 7:e33772. (SCI)
26. Hung-Chuan Pan, Ya-Ting Wu, Shih-Cheng Shen, Chi-Chung Wang, Ming-Shun Tsai, Fu-Chou Cheng, Shinn-Zong Lin, Ching-Wen Chen, Ching-San Liu, Hong-Lin Su*. (2011) Characterization of Axon Formation in the Embryonic Stem Cell-Derived Motoneuron. Cell Transplant. 20:493-502. (SCI)
27. Chiung-Hung Chang, Yu-Hsin Lin*, Chia-Lin Yeh, Yi-Chi Chen, Shu-Fen Chiou, Yuan-Man Hsu, Yueh-Sheng Chen, Chi-Chung Wang. (2010) Nanoparticles Incorporated in pH-Sensitive Hydrogels as Amoxicillin Delivery for Eradication of Helicobacter pylori. Biomacromolecules. 11:133-142. (SCI)
28. Huei-Wen Chen, Jen-Yi Lee, Ji-Ying Huang, Chi-Chung Wang, Wan-Jiun Chen, Sheng-Fang Su, Chia-Wen Huang, Chao-Chi Ho, Jeremy J.W. Chen, Meng-Feng Tsai, Sung-Liang Yu, and Pan-Chyr Yang*. (2008) Curcumin Inhibits Lung Cancer Cell Invasion and Metastasis through the Tumor Suppressor HLJ1. Cancer Res. 68:7428-7438. (SCI)
29. Chi-Chung Wang, Meng-Feng Tsai, Ting-Hao Dai, Tse-Ming Hong, Wing-Kai Chan, Jeremy JW Chen*, and Pan-Chyr Yang*. (2007) Synergistic Activation of the Tumor Suppressor, HLJ1, by the Transcription Factors YY1 and Activator Protein 1. Cancer Res. 67:4816-4826. (SCI)
30. Meng-Feng Tsai, Chi-Chung Wang#, Gee-Chen Chang, Chih-Yi Chen, Hsuan-Yu Chen, Chiou-Ling Cheng, Yu-Ping Yang, Chun-Yi Wu, Fu-Yuan Shih, Chun-Chi Liu, Hsiu-Ping Lin, Yuh-Shan Jou, Shu-Chen Lin, Chung-Wu Lin, Wei J Chen, Wing-Kai Chan, Jeremy JW Chen*, and Pan-Chyr Yang*. (2006) A new tumor suppressor HLJ1 and survival of patients with non-small cell lung carcinoma. J. Natl. Cancer Inst. 98:825-838. (SCI)
#joint first authors
31. Chi-Chung Wang, Jeremy JW Chen*, Pan-Chyr Yang*. (2006) Multifunctional transcription factor YY1: a therapeutic target in human cancer? Expert. Opin. Ther. Targets. 10: 253-266. (SCI)
32. Chi-Chung Wang, Meng-Feng Tsai, Tse-Ming Hong, Gee-Chen Chang, Chih-Yi Chen, Wen-Ming Yang, Jeremy JW Chen, and Pan-Chyr Yang*. (2005) The Transcriptional Factor YY1 Up-regulates the Novel Invasion Suppressor HLJ1 Expression and Inhibits Cancer Cell Invasion. Oncogene 24: 4081-4093. (SCI)
33. Yung-An Lee* and Chi-Chung Wang. (2000) The design of specific primers for the detection of Ralstonia solanacearum in soil samples by polymerase chain reaction. Bot. Stud. (Bot. Bull. Acad. Sin.) 41: 121-128. (SCI)
1. Zhong-Xuan Dung, Yi-Hsin Tseng, Chi-Chung Wang. Transcription factor YY1 upregulates ID2 expression and inhibits lung cancer cell growth capability. Jul 1-2, 2023, Okinawa, Japan, 2023 Taiwan-Japan Joint Conference. (Poster No. 2023-P-05)
2. Yi-Hua Lai, Yu-Lin Ai, Chi-Chung Wang, Meng-Feng Tsai, Sheng-Fang Su, Huei-Wen Chen and Jeremy J.W. Chen. Drug Screenings of Inhibiting Lung Cancer Angiogenesis by VEGF Promoter Reporter Gene Assay. September 26-28, 2019, Kyoto, Japan, The 78th annual meeting of the Japan Cancer Association. (Abstract No. E3024)
3. Su-Yun Tsai, Chi-Chung Wang. Identification of the potential promoter region and transcription factors of HMGA1 gene in human lung cancer cells. Aug 31-Sep 1, 2018, Okinawa, Japan, 2018 Taiwan-Japan Joint Conference for Genomic and Proteogenomics & Annual Retreat of Taiwan Genomics and Genetics Society. (Poster No. 2018-P-18)
4. Wan-Hua Peng, Su-Yun Tsai, Chian-Yu Wang, Bin-Huei Chen, Chi-Chung Wang. Nano-EGCG could inhibit lung cancer cell progression partially through AMPK activation. Aug 31-Sep 1, 2018, Okinawa, Japan, 2018 Taiwan-Japan Joint Conference for Genomic and Proteogenomics & Annual Retreat of Taiwan Genomics and Genetics Society. (Poster No. 2018-P-19)
5. Su-Yun Tsai, Jian-Ting Chen, Chi-Chung Wang. Cloning and characterization of human HMGA1 gene promoter. Mar 24-25, 2018, Taipei, Taiwan. The 33rd Joint Annual Conference of Biomedical Science. (Abstract No. PY090)
6. Jian-Ting Chen, Chi-Chung Wang. The functional effects of inhibitor of DNA binding 2 in human lung cancer. Mar 24-25, 2018, Taipei, Taiwan. The 33rd Joint Annual Conference of Biomedical Science. (Abstract No. PY189)
7. Sheng-Yi Lin, Yu-Han Huang, Yi-Hua Lai, Sung-Liang Yu, Sheng-Fang Su, Tse-Ming Hong, Gee-Chen Chang, Chi-Chung Wang, Jeremy J.W. Chen. The role of paired-like homeodomain 2B in non-small cell lung cancer progression. April 1-5, 2017, Washington, DC, USA, American Association for Cancer Research 110th Annual Meeting. (Abstract No. 4450)
8. Kang-Yi Su, Jau-Tsuen Kao, Hsuan-Yu Chen, Yi-Lin Chen, Chi-Chung Wang, Gee-Chen Chang, Chao-Chi Ho, Sung-Liang Yu. Routine Pharmacogenomic Testing of Lung Cancer in Taiwan. June 3-7, 2016, Chicago, IL, USA, 2016 American Society of Clinical Oncology Annual Meeting. (Abstract No. 163192)
9. Min-Yu Lin, Chian-Yu Wang, Shu-Ya Yang, Bin-Huei Chen, Chi-Chung Wang. Nano-EGCG could inhibit lung cancer cell progression partially through p53 and CRMP-1 activation. May 14-15, 2016, Taipei, Taiwan, 21th Taiwan Joint Cancer Conference (Abstract No. B1-056)
10. Szu-Hua Pan, Yuan-Ling Hsu, Chi-Chung Wang, Pei-Fang Hung and Chia-Jen Wang. Id4 Inhibits Cancer Metastasis through EMT Regulation in Lung Cancer. April 18-22, 2015, Philadelphia, USA, American Association for Cancer Research 106th Annual Meeting. (Abstract No. 1431)
11. Yuan-Ling, Hsu, Szu-Hua Pan, Chi-Chung Wang. The Functional Characterization of Inhibition of DNA Binding 4 in Human Lung Adenocarcinoma Cells. October 3-5, 2013, Yokohama, Japan, The 72nd Annual Meeting of the Japanese Cancer Association. (Abstract No. 30100)
12. Chi-Chung Wang, Yi-Hua Lai, Yu-Lin Ai, Huei-Wen Chen, Hsuan-Yu Chen, and Jeremy J.W. Chen. VEGF-targeting drug-screening identified a novel compound that can suppress tumor growth, invasion, and angiogenesis in non-small cell lung cancer. February 21-25, 2013, Maui, HA, USA, 9th Joint Conference of AACR/JCA (Abstract No. B67)
13. Chi-Chung Wang, Sung-Liang Yu, Chiou-Ling Cheng, Hsuan-Yu Chen, Ang Yuan, Huei-Wen Chen, and Jeremy J. W. Chen. Paired-like homeodomain transcription factor 2 promotes tumorigenesis in non-small-cell lung cancer. September 19-21, 2012, Sapporo, Japan, The 71st Annual Meeting of the Japanese Cancer Association. (Abstract No. P3041)
14. Ya-Jung Liu, Sung-Liang Yu, Kang-Yi Su, Jeremy J. W. Chen, and Chi-Chung Wang. Overexpression of Homeobox A5 decreases the invasive and migration capabilities of lung cancer cells. March 31-April 4, 2012, Chicago, IL, USA, American Association for Cancer Research 103th Annual Meeting. (Abstract No. 4320)
15. Chi-Chung Wang, Sheng-Yi Lin , Yi-Hua Lai, Ya-Jung Liu, Yuan-Lin Hsu, Ai-Me Lin, Pan-Chyr Yang, and Jeremy J.W. Chen. Dimethyl sulfoxide promotes the multiple functions of tumor suppressor HLJ1 through Activator Protein-1 activation in human lung carcinoma CL1-5 cells. April 2-6, 2011, Orlando, FL, USA, American Association for Cancer Research 102th Annual Meeting. (Abstract No. 2360)
16. Ching-Hsien Chen, Sheng-Yi Lin, Hsuan-Yu Chen, Chi-Chung Wang, Jeremy J.W. Chen. Acidic stress facilitates tyrosine phosphorylation of HLJ1 to associate with actin cytoskeleton in lung cancer cells. February 5-9, 2010, Waikoloa, Hawaii, USA. Eighth Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association. (Abstract No. C68)
17. Sheng-Yi Lin, Chi-Mei, Hsueh, Sung-Liang Yu, Chi-Chung Wang, Gee-Chen Chang, Jeremy J.W. Chen. Ectopic expression of a novel tumor suppressor DnaJ-like Heat Shock Protein, HLJ1, enhances ultraviolet-induced apoptosis in non-small cell lung carcinoma. April 18-22, 2009, Denver, CO, USA, American Association for Cancer Research 100th Annual Meeting. (Abstract No. 4455)
18. Hao-Wei Cheng, Yi-Fang Chen, Po-Yen Wan, Ang Yuan, Jian-Wei Jeremy Chen, Sung-Liang Yu, Chi-Chung Wang, Pan-Chyr Yang. Identification of differentially expressed miRNAs in lung cancer cell with 4 VEGF isoforms overexpression. April 12-16, 2008, San Diego, CA, USA, American Association for Cancer Research 99th Annual Meeting. (Abstract No. 440)
19. Chi-Chung Wang, Meng-Feng Tsai, Tse-Ming Hong, Ting-Haw Dai, Jeremy J. W. Chen, Pan-Chyr Yang. Cloning and characterization of the novel invasion suppressor HLJ1 enhancer. April 1-5, 2006, Washington, DC, USA,American Association for Cancer Research 97th Annual Meeting. (Abstract No. 887)
20. Huei-Wen Chen, Jeremy JW Chen, Chi-Chung Wang, Sung-Liang Yu, Ann-Lii Cheng, Ying-Shan Lee, Pan-Chyr Yang. Curcumin induces the novel tumor suppressor, HLJ1, through JunD pathway and inhibits lung cancer cell invasion. April 1-5, 2006, Washington, DC, USA, American Association for Cancer Research 97th Annual Meeting. (Abstract No. 1322)
21. Yuan-Ling Hsu, Chi-Chung Wang. The functional characterization of inhibition of DNA binding 4 in human lung adenocarcinoma cells. 台灣基因體暨遺傳學會 2011年轉譯醫學研討會暨論文競賽中興大學惠蓀林場December 16-17, 2011.
22. Jeremy J.W. Chen, Chi-Chung Wang, Meng-Feng Tsai, Ting-Hao Dai, Gee-Chen Chang, Pan-Chyr Yang. HLJ1 is a novel invasion and tumor suppressor. Symposium of the National Research Program for Genomic Medicine.NTHU Inteational Convention Center, Taipei, Taiwan, February 11-12, 2007, pp. 39.
23. Chi-Chung Wang, Meng-Feng Tsai, Tse-Ming Hong, Ting-Haw Dai, Jeremy J. W. Chen, Pan-Chyr Yang. Cloning and characterization of the novel invasion suppressor HLJ1 enhancer. April 1-5, 2006, Washington, DC, USA, American Association for Cancer Research 97th Annual Meeting. (Abstract No. 887)
24. Huei-Wen Chen, Jeremy JW Chen, Chi-Chung Wang, Sung-Liang Yu, Ann-Lii Cheng, Ying-Shan Lee, Pan-Chyr Yang. Curcumin induces the novel tumor suppressor, HLJ1, through JunD pathway and inhibits lung cancer cell invasion. April 1-5, 2006, Washington, DC, USA, American Association for Cancer Research 97th Annual Meeting. (Abstract No. 1322)
25. Chi-Chung Wang, Jeremy JW Chen, Pan-Chyr Yang. Molecular cloning and characterization of the human HLJ1 gene promoter. March 27-31, 2004, Orlando, Florida, USA, American Association for Cancer Research 95th Annual Meeting. (Abstract No. 949)
26. Meng-Feng Tsai, Chi-Chung Wang, Chiung-Yao Juan, Hsang-Yu Chen, Chun-Yi Wu, Pan-Chyr Yang, Jeremy J. W. Chen. Overexpression of HLJ1 in lung adenocarcinoma cells lead to suppression of tumor growth and cell invasive competence. March 27-31, 2004, Orlando, Florida, USA, American Association for Cancer Research 95th Annual Meeting. (Abstract No. 1848)
27. Chi-Chung Wang, Meng-Feng Tsai, Chun-Yi Wu, Pan-Chyr Yang, Jeremy J. W. Chen. HLJ1, A Novel Invasion Suppressor Gene in Lung Cancer. July 11-14, 2003, Washington D.C., USA. American Association for Cancer Research. (Abstract only #5906)
28. Jeremy J.W. Chen, Pan-Chyr Yang, Meng-Feng Tsai, Chi-Chung Wang, Pei-Li Yao, Yi-Chen Lin, Hsang-Yu Chen, Chun-Houh Chen. Genome-wide profiles of lung cancer metastasis-related genes. Symposium of the National Research Program for Genomic Medicine (III). GIS Inteational Convention Center, Taipei, Taiwan, November 2, 2003, pp. 125-126.
29. Yung-An Lee, Chi-Chung Wang, Lin-Ya Chiu, Chin-Jin Li. A DNA fragment specific to Ralstonia solanacearum contains genes related to ribose-phosphate pyrophosphokinase and thymidine phosphorylase gene. 1998. Plant Pathol. Bull. 7: 219 (Abstract).
30. 李永安、王啟仲、林芸薇. 茄科細菌性萎凋病之分生檢測法. 1998. 植物病原鑑定與病害診斷研習會專刊81-92.
31. Chi-Chung Wang, Yun-Wei Lin, Yung-An Lee. Isolation of specific probe and detection of Pseudomonas solanacearum based on PCR analyses. 1996. Plant Pathol. Bull. 5: 211 (Abstract)
32. Chi-Chung Wang, Yung-An Lee. Isolation of specific probes for plant pathogenic bacteria by a DNA subtractive hybridization. 1994. Plant Pathol. Bull. 3: 236 (Abstract).
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1. The effects of the interaction between HOXA5 and HMGA1 on lung cancer metastasis progression (MOST, 2015/8/1~2016/7/31)
2. To estimate the anti-cancer abilities and the possible molecular mechanisms of novel compounds 2878 and 2882 in lung cancer cells (CMFJ, 2013/10/01~2014/09/30)
3. Novel invasion suppressor HOXA5-targeting Chinese herbal medicine screening and related molecular mechanisms research in non-small-cell lung cancer (NSC, 2013/8/1~2014/7/31)
4. Evaluation of the inhibitory effect of EGCG nanoemulsions on cancer metastasis and its mechanism (NSC, 2012/8/1~2013/7/31)
5. Genomic expression profiling of the neuroblastoma cells by low power He-Ne laser administration (Cardinal Tien Hospital, 2011/01/01~2011/12/31)
6. Regulation Mechanisms of Novel Invasion Suppressor HOXA5 in Lung Cancer Progression (NSC99, 2010/8/1~2013/7/31)
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Lung cancer has become the most common cause of cancer deaths in the world. Metastasis, the malignant cancer cells from their primary regions of origin to distant secondary ones within the body, is the major cause leading to mortality for cancer patients. In our previous studies, using invasion/metastasis cell line model and microarray technology, we have identified several candidate genes that may play important roles in tumor growth and metastasis. Thus, the research interest of our lab is to identify the roles and molecular mechanisms of theses metastasis-related genes. In addition, the basic research results and clinical outcome of patients will be combined to examine whether these candidate genes would be served as biomarkers. Furthermore, the transcriptional regulation mechanisms of theses candidate genes will also be investigated to understand how to reduce or inhibit tumor cell metastasis. Another research interest is to identify the novel chemical compounds or Chinese herbal extracts that could inhibit the cancer progression using our platform developed.
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