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Current
Position
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Assistant Professor |
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Education and Experience
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1. 長庚大學博士後研究員
2. 長庚大學生物醫學研究所博士
3. 長庚大學基礎醫學研究所碩士
4. 長庚大學醫事技術學系
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Specialty
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Signaltransduction |
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Research / Course
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Cellular Signal Transduction
Pulmonary and Vascular Inflammation |
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1. Hsu PS, Wu CS, Chang JF, Lin WN. Leptin Promotes cPLA2 Gene Expression through Activation of the MAPK/NF-κB/p300 Cascade. Int J Mol Sci. 2015 (Accepted)
2. Lin CC§, Lin WN§, Hou WC, Hsiao L, Yang CM. Endothelin-1 Induces VCAM-1 Expression-Mediated Inflammation via Receptor Tyrosine Kinases and Elk/p300 in Human Tracheal Smooth Muscle Cells. Am J Physiol Lung Cell Mol Physiol. 309:L211-225, 2015. (§Equal contribution)
3. Lee IT, Lin CC, Lin WN, Wu WL, Hsiao LD, Yang CM. Lung inflammation caused by adenosine-5'-triphosphate is mediated via Ca(2+)/PKCs-dependent COX-2/PGE2 induction. Int J Biochem Cell Biol. 8:1657-68, 2013.
4. Lin CC, Lee IT, Wu WL, Lin WN, Yang CM. Adenosine triphosphate regulates NADPH oxidase activity leading to hydrogen peroxide production and COX-2/PGE2 expression in A549 cells. Am J Physiol Lung Cell Mol Physiol. 303:L401-L412, 2012.
5. Lin CC*, Lin WN*, Cheng SE, Tung WH, Wang HH, Yang CM. Transactivation of EGFR/PI3K/Akt involved in ATP-induced inflammatory protein expression and cell motility. J Cell Physiol. 227:1628-1638, 2012. (*Equal contribution)
6.Lin WN*, Lin CC*, Cheng HY, Yang CM. Regulation of cyclooxygenase-2 and cytosolic phospholipase A2 gene expression by lipopolysaccharide through the RNA-binding protein HuR: involvement of NADPH oxidase, reactive oxygen species and mitogen-activated protein kinases. Br J Pharmacol. 163:1691-1706, 2011. (*Equal contribution) (SCI: 4.925)
7.Lee CW, Lee IT, Lin CC, Lee HC, Lin WN, Yang CM. Yang. Activation and induction of cytosolic phospholipase A2 by IL-1beta in human tracheal smooth muscle cells: role of MAPKs/p300 and NF-kB. J Cell Biochem. 109:1045-1056, 2010.(SCI: 3.122)
8.Lin WN, Luo SF, Lin CC, Hsiao LD, Yang CM. Differential involvement of PKC-dependent MAPKs activation in lipopolysaccharide-induced AP-1 expression in human tracheal smooth muscle cells. Cell Signal. 21:1385-1395, 2009. (SCI: 4.243)
9.Luo SF, Chang CC, Lee IT, Lee CW, Lin WN, Lin CC, Yang CM. Activation of ROS/NF-kB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1b-treated human tracheal smooth muscle cells. Toxicol Appl Pharmacol. 237:8-21, 2009. (SCI: 3.993)
10.Lin CC*, Lin WN*, Wang WJ, Sun CC, Tung WH, Wang HH, Yang CM. Yang. Functional coupling expression of COX-2 and cPLA2 induced by ATP in rat vascular smooth muscle cells: role of ERK1/2, p38 MAPK, and NF-kB. Cardiovasc Res. 82:522-531, 2009. (*Equal contribution) (SCI: 6.051
11.Luo SF, Lin CC, Chen HC, Lin WN, Lee IT, Lee CW, Hsiao LD, Yang CM. Involvement of MAPKs, NF-kB and p300 co-activator in IL-1b-induced cytosolic phospholipase A2 expression in canine tracheal smooth muscle cells. Toxicol Appl Pharmacol. 232:396-407, 2008. (SCI: 3.993)
12.Lin WN, Luo SF, Wu CB, Lin CC, Yang CM. Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: Involvement of Src/EGFR/PI3-K/Akt pathway. Toxicol Appl Pharmacol. 228:256-268, 2008. (SCI: 3.993)
13.Lin WN, Luo SF, Lee CW, Wang CC, Wang JS, Yang CM. Involvement of p42/p44 MAPK, p38 MAPK, JNK and NF-kB in LPS-induced VCAM-1 expression in human tracheal smooth muscle cells. Cell Signal. 19:1258-1267, 2007. (SCI: 4.243)
10.Lee CW, Lin CC, Lin WN, Liang KC, Luo SF, Wu CB, Wang SW, Yang CM. TNF-a induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-kB/p300 binding in human tracheal smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 292: L799-L812, 2007. (SCI: 4.132)
15.Liang KC, Lee CW, Lin WN, Lin CC, Wu CB, Luo SF, Yang CM. Interleukin-1β induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK and nuclear factor-kB signaling pathways in human tracheal smooth muscle cells. J Cell Physiol. 211:759-770, 2007. (SCI: 3.986)
16.Lee CW, Lin WN, Lin CC, Luo SF, Wang JS, Pouyssegur J, Yang CM. Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-a in human tracheal smooth muscle cells: Involvement of MAPKs, NF-kB, p300, and histone acetylation. J Cell Physiol. 207: 174-186, 2006. (SCI: 3.986)
17.Luo SF, Lin WN, Yang CM, Lee CW, Liao CH, Leu YL, Hsiao LD. Induction of cytosolic phospholipase A2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of MAPKs and NF-kB pathways. Cell Signal. 18: 1201-1211, 2006. (SCI: 4.243)
18.Wang CC, Lin WN, Lee CW, Lin CC, Luo SF, Wang JS, Yang CM. Involvement of p42/p44 MAPK, p38 MAPK, JNK and NF-kB in interleukin-1b-induced VCAM-1 expression in human tracheal smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 288: L227-L237, 2005. (SCI: 4.132)
19.林維寧. 探討LPS誘發氣管平滑肌細胞黏附分子與cytosolic phospholipase A2 表現的機轉. 九十六年度 長庚大學 博士論文
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1. Sia KC, Wu CS, Lin WN. LPS facilitated preadipocytes proliferation via NADPH oxidase/ROS-dependent expression of cyclooxygenase-2. The 30th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2015. Poster.
2. Wu CS, Hsu PS, Lin WN. Leptin modulated the occurrence of lung inflammation by increased expression of cPLA2 and COX‐2 via NADPH oxidase/ROS‐dependent activation of AP‐1. The 30th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2015. Poster. (中國生理學會104年度優秀論文獎第二名).
3. Hsu PS, Wu CS, Lin WN. Enhancement of lung inflammatory protein expression by leptin via MAPK, NF-kappaB and p300. 102年度形態及生理醫學學門新知暨學術交流研討會. Poster.
4. Chen HM, Lin WN. Adiponectin Modulated Expression of Cytosolic Phospholipase A2 and Cyclooxygenase-2 via Accumulation of ROS and Activation of PKC/p300 in the Pulmonary Alveolar Type II Cells. The 29th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2015. Poster.
5. Lin WN, Tung WH, Wang HH, Yang CM. Functional Coupling Expression of COX-2 and cPLA2 Induced by ATP in Rat Vascular Smooth Muscle Cells. The 9th World Congress on Inflammation, Tokyo, Japan. July6-10, 2009. Poster.
6. Lin WN, Yang CM. Up-regulation of VCAM-1 Ehanced Leukocytes Recruitment to the Lung in LPS-induced Airway Diseases. The 24th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2009. Poster.
7. Lin WN, Yang CM. LPS Induces VCAM-1 Expression via Src/EGFR/PI3-K/Akt Pathway in Human Tracheal Smooth Muscle Cells. 32nd FEBS Congress on Molecular Machines, Vienna, Austria. July 7-12, 2007. Poster.
8. Lin WN, Yang CM. MECHANISMS INVOLVED in REGULATION of VCAM-1 EXPRESSION via Src/EGFR/PI3-K/Akt PATHWAY in TRACHEAL SMOOTH MUSCLE CELLS. The 22th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2007. Poster.
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1. Effects of bacterial endotoxin on hypertropic obesity (Cathay General Hospital, 2015/08~ 2016/07)
2. Melatonin attenuated lung inflammation via regulating the balance of intracellular oxidative stress (Shin Kong Wu Ho-Su Memorial Hospital, 2015/01~ 2015/12)
3. LPS modulated cell viability of preadipocytes via cyclooxygenase-2 (Cathay General Hospital, 2014/08~ 2014/07)
4. Effect of leptin on modulating acute and chronic lung inflammation in mice (Shin Kong Wu Ho-Su Memorial Hospital, 2014/01~ 2014/12)
5. Roles of cytosolic phospholipase A2 in lipopolysaccharide-stimulated proliferation of preadipocytes (Cathay General Hospital, 2013/08~ 2014/07)
6.Effects of bacterial infection on adipogenesis: implicated on hyperplasia and hypertrophy of obesity (Ministry of Science and Technology of Taiwan, 2013/08~2014/07)
7. Mechanisms underlying leptin stimulated expression of cyclooxygenase-2 in lung type II alveolar cells (Cardinal Tien Hospital, 2013/01~2013/12)
8. Participation of NADPH oxidase/ROS/CREB pathway in leptin-stimulated cPLA2 expression in alveolar type II epithelial cells (Shin Kong Wu Ho-Su Memorial Hospital, 2013/01~ 2013/12)
9. Mechanisms underlying lipopolysaccharide-mediated preadipocyte proliferation (Cathay General Hospital, 2012/08~ 2013/07)
10. Effects of nanocatechin on lipid metabolism: expression of aquaporin 3, 7 and 9 (Ministry of Science and Technology of Taiwan, 2012/08~2013/07)
11. Leptin induces cytosolic phospholipase A2 expression in human alveolar type II epithelial cells: involvement of MAPK, AMPK and p300 (Shin Kong Wu Ho-Su Memorial Hospital, 2012/01~2012/12)
12. Mechanisms underlying leptin-induced expression of intracellular adhesion molecules in lung epithelial cells (Far Eastern Memorial Hospital, 2011/08~ 2012/07)
13. Mechanisms underlying adipokine mediated pulmonary inflammation (Shin Kong Wu Ho-Su Memorial Hospital, 2011/01~ 2011/12)
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Obesity, a chronic disease, is a worldwide epidemic problem and contributes to the development of a group of potentially life-threatening conditions such as Diabetes Mellitus, dyslipidemia, cardiovascular disease, metabolic syndrome, and some cancer. Recently, obesity has been found to relate to various pulmonary diseases, including obstructive sleep apnea, asthma, acute lung injury, and chronic obstructive pulmonary disease. However, how obesity contributes to the occurrence of pulmonary diseases is largely unknown. It is known, however, that a pulmonary inflammatory response occurs during recovery from exogenous infection or injury of the lungs and can result in lasting damage if not properly resolved. In our lab, adipokines, such as leptin and adiponectin, are used to evaluate the occurrence or exacerbation of lung inflammation and pathology in vitro in pulmonary cells or in vivo in mice model. On the other hand, inflammatory cytokines-stimulated adipocytes are used to evaluate the effects of inflammatory stimuli on hyperplasia and hypertrophy of adipose tissues. Through experimental programing and evaluation, the correlation between pulmonary system and adipose tissue will be establishment.
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