/ / /
LATEST NEWS
ABOUT US
FACULTY
COURSE
ADMISSION
FEES
SCHOLARSHIP
FACULTY
FACULTY
Name
 Ying-Hung Lin
Current Position
 Associate Professor
Extension
  
E-mail
 084952@mail.fju.edu.tw>
Education and Experience
 1. Ph.D., Graduate Institute of Basic Sciences, National Cheng Kung University, College of Medicine, Tainan, Taiwan.
2. Postdoctoral Research Fellow, Department of Obstetrics & Gynecology, National Cheng Kung University, College of Medicine, Tainan, Taiwan.
Specialty
 1.Molecular and Cellular Biology
2. Andrology, Spermatogenesis
Research/Course
 1. Identification and characterization of novel genes/proteins involved in mammalian spermatogenesis
2. Developing molecular methods for diagnosis and classification in patients presenting with spermatogenesis defects
 
 
Author
A. 學術期刊論文

  • Au CF, Wang YY, Lai TH, Chan CC, Ke CC, Chung SD*, Lin YH*. A Novel Hemizygous CDX4 Missense Variant Identified in a Taiwanese Man with Severe Teratozoospermia. Medicina 2026 Aug 62(8),1508.(* corresponding authors)

  • Chen YL, Lin WN, Pan PY, Ku WC, Wang P, Yip PK, Tsui KC, Wu YN, Lin YH*. Generation of a novel Dysferlin microdeletion knock-in mouse model mimicking muscular dystrophy-like pathology. Sci Rep. 2026 Apr 1;16(1):15322.(* corresponding authors)

  • Wang YY, Lin YH, Ke CC, Lai TH, Yu IS, Au CF, Singh R, Lin YH*. Human teratozoospermia-related AGTPBP1 R791H mutation is associated with sperm head and tail defects in a CRISPR-engineered murine model. J Assist Reprod Genet. 2026 Jan; 43(1):133-142. (* corresponding authors)

  • Pan PY, Ke CC, Wang YY, Lin YH, Ku WC, Au CF, Chan CC, Huang CY, Lin YH*.Proteomic profiling of TBC1 domain family member 21-null sperms reveals the critical roles of TEKT 1 in their tail defects. Dev Dyn. 2024 Nov;253(11):1024-1035. (* corresponding authors)

  • Lin YH, Wang YY, Lai TH, Teng JL, Lin CW, Ke CC, Yu IS, Lee HL, Chan CC, Tung CH, Conrad DF, O'Bryan MK, Lin YH*. Deleterious genetic changes in AGTPBP1 result in teratozoospermia with sperm head and flagella defects. J Cell Mol Med. 2024 Jan;28(2):e18031. (* corresponding authors)

  • Chen YL, Wu WB, Wang P, Yip PK, Wu YN*, Lin YH*, Lin WN*. Novel five nucleotide deletion in dysferlin leads to autosomal recessive limb-girdle muscular dystrophy. Physiol Rep. 2023 Dec;11(24):e15887. (* corresponding authors)

  • Wang YY, Lin YH, Wu VC, Lin YH, Huang CY, Ku WC, Sun CY. Decreased Klotho Expression Causes Accelerated Decline of Male Fecundity through Oxidative Injury in Murine Testis. Antioxidants (Basel). 2023 Aug 25;12(9):1671.

  • Huang CY, Lin YH, Kuo YT, Wang YY, Ke CC, Chan CC, Lin YH*. RAB5C is a TBC1D21 interactor involved in sperm morphology formation. Fu-Jen Joual of Medicine 2023. 21(1):15-25. (* corresponding authors)

  • Tsai YL, Lai TH, Liu HC, Wang YY, Lin YH, Ke CC, Chung MT, Chan CC, Lin YH*. Localization Pattes of RAB3C Are Associated with Murine and Human Sperm Formation. Medicina (Kaunas). 2022 Oct 7;58(10):1408. (* corresponding authors)

  • Lin YH, Wang CC, Lin YH, Chen BH. Preparation of Catechin Nanoemulsion from Oolong Tea Leaf Waste and Its Inhibition of Prostate Cancer Cells DU-145 and Tumors in Mice. Molecules. 2021 May 28;26(11):3260.

  • Lin YH, Huang CY, Ke CC, Wang YY, Lai TH, Liu HC, Ku WC, Chan CC, Lin YH*. ACTN4 Mediates SEPT14 Mutation-Induced Sperm Head Defects. Biomedicines 2020, 8, 518. (* corresponding authors)
  • Wang YY, Ke CC, Chen YL, Lin YH, Yu IS, Ku WC, O'Bryan MK, Lin YH*. Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice. PLoS Genet. 2020 25;16(9):e1009020. (* corresponding authors)

  • Wang YY, Lai TH, Chen MF, Lee HL, Kuo PL, Lin YH*. SEPT14 Mutations and Teratozoospermia: Genetic Effects on Sperm Head Morphology and DNA Integrity. J Clin Med. 2019 Aug 23;8(9). pii: E1297. (* corresponding authors)

  • Wu YN, Chen KC, Wu CC, Lin YH*, Chiang HS*. SLC9A3 Affects Vas Deferens Development and Associates with Taiwanese Congenital Bilateral Absence of the Vas Deferens. Biomed Res Int. 2019 Mar 10;2019: 3562719. (*co-corresponding authors)

  • Yeh CH, Wang YY, Wee SK, Chen MF, Chiang HS, Kuo PL*, Lin YH*. Testis-Specific SEPT12 Expression Affects SUN Protein Localization and is Involved in Mammalian Spermiogenesis. Int J Mol Sci. 2019 Mar 7;20(5). pii: E1163. (*co-corresponding authors)

  • Chiang HS, Wang YY, Lin YH, Wu YN. The role of SLC9A3 in Taiwanese patients with congenital bilateral absence of vas deferens (CBAVD). J Formos Med Assoc. 2019 Feb 20. pii: S0929-6646(18)30529-1.

  • Ke CC*,Lin YH*, Wang YY, Wu YY, Chen MF, Ku WC, Chiang HS, Lai TH. TBC1D21 Potentially Interacts with and Regulates Rap1 during Murine Spermatogenesis. Int. J. Mol. Sci. 2018, 19(11),3292 (*co-first authors)

  • Huang CY, Wang YY, Chen YL, Chen MF, Chiang HS, Kuo PL*,Lin YH*.CDC42 Negatively Regulates Testis-Specific SEPT12 Polymerization. Int J Mol Sci. 2018 Sep 5;19(9). pii: E2627. (*co- corresponding authors)

  • Wang YY, Chiang HS, Cheng CY, Wu YN, Lin YC, HC Liu, Tsai WK, Chen YL, Lin YH*. SLC9A3 protein is critical for acrosomal formation in postmeiotic male germ cells. Int J Mol Sci. 2017 Dec 29;19(1). pii: E103 (*corresponding author)

  • Wang YY*, Lin YH*, Wu YN*, Chen YL, Lin YC, Cheng CY, Chiang HS. Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice. PLoS Genetics. 2017 Apr 6;13(4):e1006715 (*co-first authors)
  • Lin YH*, Ke CC*, Wang YY, Chen MF, Chen TM, Ku WC, Chiang HS, Yeh CH. RAB10 Interacts with the Male Germ Cell-Specific GTPase-Activating Protein during Mammalian Spermiogenesis.Int J Mol Sci. 2017 Jan 5;18(1). pii: E97. (*co-first authors)
  • Lai TH, Wu YY, Wang YY, Chen MF, Wang P, Chen TM, Wu YN, Chiang HS, Kuo PL, Lin YH*. SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis. Int J Mol Sci. 2016 Nov 16;17(11). pii: E1911.(*corresponding authors)
  • Liao CH, Wu YN, Chen BH, Lin YH, Ho HO, Chiang HS. Neuroprotective effect of docosahexaenoic acid nanoemulsion on erectile function in a rat model of bilateral caveous nerve injury. Sci Rep. 2016 Sep 14;6:33040.
  • Lin CY, Chen CY, Yu CH, Yu IS, Lin SR, Wu JT, Lin YH, Kuo PL, Wu JC, Lin SW. Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. Sci Rep. 2016 Feb 2;6:20227.
  • Liao CH, Chen BH, Chiang HS, Chen CW, Chen MF, Ke CC, Wang YY, Lin WN, Wang CC, Lin YH*. Optimizing a Male Reproductive Aging Mouse Model by D-Galactose Injection. Int J Mol Sci. 2016 Jan 13;17(1). pii: E98. (*corresponding authors)
  • Yeh CH, Kuo PL, Wang YY, Wu YY, Chen MF, Lin DY, Lai TH, Chiang HS, Lin YH*. SEPT12/SPAG4/LAMINB1 complexes are required for maintaining the integrity of the nuclear envelope in postmeiotic male germ cells. PLoS One. 2015 Mar 16;10(3):e0120722.(*corresponding authors)
  • Kuo YC, Shen YR, Chen HI, Lin YH, Wang YY, Chen YR, Wang CY, Kuo PL. SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins. J Cell Sci. 2015 Mar 1;128(5):923-34.
  • Kuo PL, Chiang HS, Wang YY, Kuo YC, Chen MF, Yu IS, Teng YN, Lin SW, Lin YH*. SEPT12-microtubule complexes are required for sperm head and tail formation. Int J Mol Sci. 2013 Nov 7;14(11):22102-16. (*corresponding authors)
  • Tasi YC, Chao HC, Chung CL, Liu XY, Lin YM, Liao PC, Pan HA, Chiang HS, KuoPL*, Lin YH*. Characterization of 3-hydroxyisobutyrate dehydrogenase, HIBADH, as a sperm-motility marker. J Assist Reprod Genet. 2013 Apr;30(4):505-12.(*corresponding authors)
  • Lin YH*, Wang YY, Chen HI, Kuo YC, Chiou YW, Lin HH, Wu CM, Hsu CC, Chiang HS, Kuo PL. SEPTIN12 genetic variants confer susceptibility to teratozoospermia. PLoS One. 2012;7(3):e34011. (* first author)
  • Kuo YC, Lin YH, Chen HI, Wang YY, Chiou YW, Lin HH, Pan HA, Wu CM, Su SM, Hsu CC, Kuo PL. SEPT12 mutations cause male infertility with defective sperm annulus. Hum Mutat. 2012 Apr;33(4):710-9.
  • Lin YH*, Lin YM, Kuo YC, Wang YY, Kuo PL. Identification and characterization of a novel Rab GTPase-activating protein in spermatids. Int J Androl. 2011 Oct;34(5 Pt 2):e358-67. (* first author)
  • Lin YH*, Kuo YC, Chiang HS, Kuo PL. The role of the septin family in spermiogenesis. Spermatogenesis. 2011 Oct;1(4):298-302. (* first author)
  • Lin YH*, Chou CK, Hung YC, Yu IS, Pan HA, Lin SW, Kuo PL. SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos. Fertil Steril. 2011 Jan;95(1):363-5. (* first author)
  • Chao HC*, Lin YH*, Kuo YC, Shen CJ, Pan HA, Kuo PL. The expression patte of SEPT7 correlates with sperm morphology. J Assist Reprod Genet. 2010Jun;27(6):299-307. (*co-first authors)
  • Lin YH*, Lin YM, Wang YY, Yu IS, Lin YW, Wang YH, Wu CM, Pan HA, Chao SC, Yen PH, Lin SW, Kuo PL. The expression level of septin12 is critical for spermiogenesis. Am J Pathol. 2009 May;174(5):1857-68. (* first author)
  • Teng YN, Lin YH, Tsai YC, Hsu CC, Kuo PL, Lin YM. A simplified gene-specific screen for Y chromosome deletions in infertile men. Fertil Steril. 2007 Jun;87(6): 1291-300.
  • Lin YH*, Lin YM, Teng YN, Hsieh TY, Lin YS, Kuo PL. Identification of ten novel genes involved in human spermatogenesis by microarray analysis of testicular tissue. Fertil Steril. 2006 Dec;86(6):1650-8. (* first author)
  • Cheng YS, Kuo PL, Teng YN, Kuo TY, Chung CL, Lin YH, Liao RW, Lin JS, Lin YM. Association of spermatogenic failure with decreased CDC25A expression in infertile men. Hum Reprod. 2006 Sep;21(9):2346-52.
  • Hsu CC, Kuo PL, Chuang L, Lin YH, Teng YN, Lin YM. Uniform deletion junctions of complete azoospermia factor region c deletion in infertile men in Taiwan. Asian J Androl. 2006 Mar;8(2):205-11.
  • Lin YM, Teng YN, Chung CL, Tsai WC, Lin YH, Lin JS, Kuo PL. Decreased mRNA transcripts of M-phase promoting factor and its regulators in the testes of infertile men. Hum Reprod. 2006 Jan;21(1):138-44.
B. Conference Paper
1.Lin YH. Using knockout mice and Proteomic tools to study the roles of testis-specific Rab GTPase-Activing Protein during mammalian spermatogenesis. Inteational Federation of Fertility Societies /Japanese Society for Reproductive Medicine (IFFS/JSRM). Pacifico Yokohama, Japan, 2015. (Travel Support and Oral Presentation Award)
 
2.Lin YH. SEPT12-Microtubule Complexes Are Required for Sperm Head and Tail Formation. The Taiwan Association of Andrology, Taipei, Taiwan, 2015. (Excellent Paper Award 2nd, Group: Basic Medicine)
 
3.Lin YH. Dynamic expression of SEPT12 affects the integration of nuclear envelope during human spermiogenesis. The 5th Congress of the Asia Pacific Initiative on Reproduction, Brisbane, Australia, 2014. (Oral)
 
4.Lin YH, Wang YY, Chiang HS, Kuo PL. SEPT12-microtubules complexes are required for sperm-head and -tail formation. 102 年度形態及生理醫學學門新知暨學術交流研討會, Poster.
 
5.Lin YH, Wang YY, Chen HI, Kuo YC, Chiou YW, Lin HH, Wu CM, Hsu CC, Chiang HS, Kuo PL. SEPTIN12 Genetic Variants Confer Susceptibility to Teratozoospermia. 台灣男性學醫學會第七屆第3次會員大會暨第39次學術演講會, Oral.
 
6. Lin YH, Wang YY, Chen HI, Kuo YC, Kuo PL. Genetic alterations and Molecular roles of SEPTIN12 in Male Infertility. The 19th symposium on the recent advances in cellular and molecular biology. 2011. (細生年會優秀壁報論文獎)
 
7. Lin YH, Wang YY, Kuo YC, Yu IS, Chou CK, Pan HA, Lin SW, Kuo PL. Decreased Septin12 causes sperm DNA damage. The 25th Joint Annual Conference of Biomedical Sciences.2010, Post, P405.
 
8. Lin YH, Kuo PL. The expression level of Septin12 is critical for spermiogenesis. The 36th Congress of the Inteational Union of Physiological Sciences. (IUPS), 2009, Kyoto, Japan. Post, P2PM-7-11.
 
9. Lin YH, Wang YY (presenter), Lin YM, Yu IS, Lin YW, Wang YH, Wu CM, Pan HA, Chao SC, Yen PH, Lin SW, Kuo PL. The expression level of Septin12 is critical for spermiogenesis. The 17th symposium on the recent advances in cellular and molecular biology. 2009: poster NO.23. (細生年會優秀壁報論文獎)
 
10. Lin YH, Lai LW, Lin YM, Teng YN, Kuo PL. Characterization of the male germ cell GAP2 in mammalian spermiogenesis. The 16th symposium on the recent advances in cellular and molecular biology. 2008: Poster NO.126.
 
11. Lin YH, Lin YM, Teng YN, Kuo PL. Identification of a novel GAP gene in mammalian spermatogenesis. The 15th symposium on the recent advances in cellular and molecular biology. 2007: poster NO.135. 
 
12. Lin YH, Kuo PL. Identification of novel sterility-related Septin12 genes in human spermatogenesis. Germ cells, 2006: poster NO.77. Cold Spring Harbor, New York, USA.
 
13. 林盈宏,林永明, 鄧燕妮,林信男,郭保麟. Identification of novel Genes Involved In Human Spermatogenesis by Microarray Analysis of Testicular Tissue. 台灣男性學醫學會95 年度第五屆第二次會員大會暨第25次學術演講會,Oral: A18. 2006/3/4
 
14. Lin YH, Lin YM, Teng YN, Kuo PL. Identification of novel genes in mammalian spermatogenesis -Septin12 gene. The 14th symposium on the recent advances in cellular and molecular biology. 2006: poster NO.120
 
15. Lin YH, Lin YM, Cheng CW, Kuo PL. A novel multiplex PCR protocol for rapid sceening of Y chromosome gene deletions in patients with spermatogenesis defects. The 9th symposium on the recent advances in cellular and molecular biology. 2001: poster NO.88
 
Research Grants

Ministry of Science and Technology of Taiwan Grants: Principal Investigator

  • Dual mechanisms of ATG3 in male reproduction through autophagy and exosome regulation (2026.08-2027.07; NSTC 115-2320-B-030-007-)
  • Identifying the novel disease genes and mutations of teratozoospermia by utilizing whole exome sequencing and mechanistic studies (2022.08- 2025.07; NSTC 111-2320-B-030 -007 -MY3 )
  • Revealing the Molecular and Pathological Mechanisms of AGTPBP1 Mutation Caused Teratozoospermia (2021.08-2022.07; MOST 110-2320-B-030-002)
  • Through NGS Screening the genetic mutations for teratozoospermia and dissecting the molecular pathological mechanism: a candidate gene AGTPBP1 (2020.08- 2021.07; MOST 109-2320-B-030-002)
  • Revealing the Possible Molecular Mechanism of SEPT14 Mutation-Caused Male Infertility (2017.08- 2020.07; MOST 106-2320-B-030-003-MY3)
  • Genetic and expression analysis of SEPT12 -interacted partner, SEPTIN14, in the infertile men (1/3)(2/3)(3/3)，(2014.08-2017.07; MOST 103-2314-B-030-002; MOST 104-2314- B-030-001 -; MOST 105-2314-B-030-001 -)
  • Using knockout mice to study the roles of testis-specific Rab GTPase-Activing Protein during mammalian spermatogenesis. (2013.08- 2016.07; NSC 102-2320-B-030-006-MY3)
  • To study pathological mechanisms of genetic alterations of SEPTIN12 in male infertility and possible therapeutical approaches using transgenic mice (2012.08- 2014.07; NSC 101- 2320 -B- 030-012-MY2)
  • Safety studies on nano-cathins and possible therapeutical effects on infertility caused by hyper-oxidation in vivo (2012.08-2013.07; NSC 101 - 2313 - B - 030- 006 -)

Other Grants : Principal Investigator

1. Cathay General Hospital (2013, 2014, 2016, 2017, 2018, 2021, 2023, 2025, 2026)

2. Shin Kong Wu HO-SU Memorial Hospital(2012, 2013, 2015, 2016, 2022, 2026)

3. Cardinal Tien Hospital (2013, 2014, 2016, 2017, 2021, 2022)

4. Chi Mei Medical Center (2011, 2016)
 
 
 
Research Laboratory
The pathology of male infertility includes anatomic defects, gametogenesis dysfunction, endocrinopathies, immunologic problems, ejaculatory failure, environmental exposures, chromosomal abnormality and gene mutations. In previous years, we focused on identification of novel genes involving in human spermatogenesis. We have identified and characterized several novel sterility-related genes, and used these genes to classify men with spermatogenic defects and tried to promote the fertility rate of these men with infertility. By microarray analysis of testicular tissues from patients with spermatogenic defects, we discovered a panel of genes which are persistently down-regulated in cases of men with spermatogenic defects. Further, we identified the function of several genes (SEPTIN12, SEPTIN7 , MgcRabGAP, and HIBADH) involved in human spermatogenesis through cell and transgenic mice model. In clinical aspect, we have identified and characterized the genetic alteations (mutations and SNPs) of SEPTIN12 gene in men with spermatogenic defects. Recently, we dissected the possible mechanism of decreased SEPT12 disorganizes the structure of microtubulin and results in spermatogenic defects.
 
 
 
 
 

 

Copyright c2009 Graduate Institute of Biomedical and Pharmaceutical Science, MD746, 7th floor, College of Medicine,
Fu Jen Catholic University, #510, Zhongzheng Rd., Xinzhuang Dist., New Taipei City 24205, Taiwan(R.O.C)
TEL. No：886-2-29053426Fax. No：886-2-29053415E-mail：GIBPS@mail.fju.edu.tw